New anthracyclinones and their production

Details New anthracyclinones and their production New anthracyclinones and their production

1983-12-23

1985-08-20

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603515, 260365, 260376, 260383, C07C 5036, C07C 4976, C07C 4974

Patent

active

045363366

ABSTRACT:
A new compound of the formula ##STR1## wherein R.sup.1 is a hydrogen atom, a hydroxyl group or an alkoxyl group of 1-4 carbon atoms and R.sup.2 is an ethyl group or acetyl group is now provided, which is an intermediate compound useful for synthesis of antitumor anthracyclines. This new anthracycline is produced by cyclization of a new compound of the formula ##STR2## wherein R.sup.1 is as defined above and TMS denotes a trimethylsilyl group, followed by decarboxylation of the cyclization product.

REFERENCES:
patent: 4012448 (1979-03-01), Smith et al.
patent: 4147706 (1979-04-01), Kende et al.
patent: 4329339 (1982-05-01), Fujiwara et al.
patent: 4415498 (1983-11-01), Anathasabramanian et al.

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