Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1990-11-14
1992-04-21
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 424423, 435177, 435180, 435182, 530399, 6048901, 6048921, A61F 200, C12N 1102, A61K 922
Patent
active
051066270
ABSTRACT:
Neurological therapy devices are disclosed for the local and controlled delivery of a neurotransmitter to the brain of a subject suffering from neurotransmitter deficiency or dysfunction. In one embodiment the device includes a biocompatible, implantable, and retrievable polymeric insert including a source of neurotransmitter embedded therein. In another embodiment, the device includes a retrievable source of neurotransmitter including at least one neurotransmitter-secreting cell encapsulated within a semipermeable membrane allowing the diffusion therethrough of the neurotransmitter, and further includes a source of growth factor in close proximity to the neurotransmitter-secreting cells.
REFERENCES:
patent: 3093831 (1963-06-01), Jordan
patent: 4241187 (1980-12-01), White
patent: 4352883 (1982-10-01), Lim
patent: 4378016 (1983-05-01), Loeb
patent: 4391909 (1983-07-01), Lim
patent: 4402694 (1983-09-01), Ash et al.
patent: 4647536 (1987-03-01), Mosbach et al.
patent: 4686098 (1987-08-01), Kopchick et al.
patent: 4883666 (1989-11-01), Sabel et al.
Calne et al. (1969), The Lancet (Nov. 8 issue), pp. 973-976.
Calne et al. (1974), British Medical Journal, vol. 4, pp. 442-444.
Langer et al. (1976), Nature, vol. 263, pp. 797-800.
Sun et al. (1977), Diabetes, vol. 26, No. 12, pp. 1136-1139.
Langer (1981), Methods in Enzymology, vol. 73, pp. 57-75.
Bjorklund et al. (1982), MacMillan Journals Ltd., Nature, vol. 298, pp. 652-654.
Brundin et al. (1985), Experimental Brain Research, vol. 60, pp. 204-208.
Hefti et al. (1985), Brain Research, vol. 348, pp. 283-288.
Olson et al. (1985), Annals of the New York Academy of Sciences, vol. 457, pp. 105-126.
Brundin et al. (1987), Annals of the New York Academy of Sciences, vol. 495, pp. 473-496.
Freed et al. (1987), Annals of the New York Academy of Sciences, vol. 495, pp. 581-597.
Kordower et al. (1987), Annals of the New York Academy of Sciences, vol. 495, pp. 606-622.
Morihisa et al. (1987), Annals of the New York Academy of Sciences, vol. 495, pp. 599-605.
Nguyen et al. (1987), Can. J. Physiol. Pharmacol., vol. 65, pp. 823-827.
Sagen et al. (1987), Annals of the New York Academy of Sciences, vol. 495, pp. 306-333.
Freed et al. (1981), Nature, vol. 292, pp. 351-352.
Schwarz et al. (1987), Annals of the New York Academy of Sciences, vol. 495, pp. 786-791.
Wells et al. (1987) Annals of the New York Academy of Sciences, vol. 495, pp. 804-806.
Aebischer et al. (1988), Society of Neuroscience (Abstract), vol. 14, p. 1311.
Aebischer et al. (1988), Brain Research, vol. 448, pp. 364-368.
McRae-Degueurce et al. (1988), Neuroscience Letters, vol. 92, pp. 303-309.
Rosenberg et al. (1988), Reports (Dec. 16), pp. 1375-1378.
Aebischer Patrick
Winn Shelley R.
Brown University Research Foundation
Engellenner Thomas J.
Kerner Ann-Louise
Kishore G. S.
Page Thurman K.
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