Neuroleptic-4-(naphthylmethyl)piperidine derivatives

Details Neuroleptic-4-(naphthylmethyl)piperidine derivatives Neuroleptic-4-(naphthylmethyl)piperidine derivatives

1979-02-09

1981-01-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546205, 546206, 546314, 546343, 546346, 546348, A01K 31445, C07D21132, C07D21122

Patent

active

042462681

ABSTRACT:
Novel compounds of the formula ##STR1## wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R.sub.1 is hydrogen, alkyl, alkoxy or halogen, X is carbonyl, hydroxymethylene or methylene, and Z is carbonyl or hydroxymethylene and their pharmaceutically acceptable acid addition salts are useful as antipsychotic agents having a low potential for extrapyramidal side effects. The novel compounds are prepared from novel intermediates of formula ##STR2## or their salts wherein R and X have the meanings defined above.

REFERENCES:
patent: 3795677 (1974-03-01), Carr
patent: 3888867 (1975-06-01), Carr
patent: 4145427 (1979-03-01), Langbein et al.
Panizzon, L., Helv. Chim. Acta, 27, 1751 (1944). _
March, J. Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 413-414. _

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