Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treat

Details Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treat Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treat

1987-12-17

1989-02-28

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540488, A61K 3133, C07D28114

Patent

active

048085804

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1 is phenyl substituted with 1 to 3 substituents selected from the group consisting of lower alkoxy and halogen; R.sub.2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy; ##STR2## or ##STR3## R.sub.3 and R.sub.4 are independently lower alkyl, phenyl lower alkyl or together form a piperidine or pyrrolidine ring; n is 2 to 4; m is 1 to 2; or pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I have activity as calcium channel blockers and accordingly, are useful as agents for lowering blood pressure, and as agents for treating ischemia.

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