Nanoparticle derivatives of gemcitabine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S043000, C536S028100

Reexamination Certificate

active

08044034

ABSTRACT:
The use of squalenic acid or a derivative thereof in formulating at least one polar active principle with a molecular weight of 100 Da or more, in the form of nanoparticles, and pharmaceutical compositions thereof.

REFERENCES:
patent: 6384019 (2002-05-01), Sandvold et al.
patent: 6524595 (2003-02-01), Perrier et al.
patent: 2002/0042391 (2002-04-01), Myhren et al.
patent: 0693077 (1996-01-01), None
patent: 9832762 (1998-07-01), None
Ceruti et al., Synthesis of (E)- and (Z)-29-methylidyne-2,3-oxidosqualene derivatives as inhibitors of liver and yeast oxidosqualene cyclase J. Chem. Soc., Perkin Trans. 1, 2002, 1477-1488.
Fessi et al., Nanocapsule formation by interfacial polymer deposition following solvent displacement International Journal of Pharmaceutics, 55 (1989) R1-R4.
Heinemann et al., Comparison of the Cellular Pharmacokinetics and Toxicity of 2′,2′-Difluorodeoxycytidine and 1-β-D-Arabinofuranosylcytosine Cancer Research 48, 4024-4031, Jul. 15, 1988.
Heinemann et al., Cellular Elimination of 2′,2′-Difluorodeoxycytidine 5′ -Triphosphate: A Mechanism of Self-Potentiation Cancer Research 52, 533-539, Feb. 1, 1992.
Hertel et al., Evaluation of the Antitumor Activity of Gemcitabine (2′ ,2′ -Difluoro-2′ -deoxycytidine) Cancer Research 50, 4417-4422, Jul. 15, 1990.
Plunkett, et al., Gemcitabine: Metabolism, Mechanisms of Action, and Self-Potentiation Seminars in Oncology vol. 22, No. 4 Suppl II Aug. 1995: pp. 3-10.
Sharma et al., Reversed-phase high-performance liquid chromatographic determination of taxol in mouse plasma Journal of Chromatography B, 655, (1994) 315-319.
Storniolo et al., Preclinical, Pharmacologic, and Phase I Studies of Gemcitabine Seminars in Oncology vol. 24, No. 2 Suppl 7 Apr. 1997: pp. S7-2-S7-7.
van Tamelen, Bioorganic Chemistry: Sterols and Acyclic Terpene Terminal Epoxides Sterols and Acyclic Terpene Terminal Epoxides Apr. 1968 111-120.
Kaul et al., Pharmaceutical Research (2002), vol. 19, pp. 1061-1067.

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