N-substituted piperidines and their use as pharmaceuticals

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S189000

Reexamination Certificate

active

08071624

ABSTRACT:
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

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Submitted to applicant with ISR of PCT/US05/22307.
Database CAPLUS on STN (Columbus, OH, USA) No. 126:317635, “Alpha-amino acids derived from ornithine as building blocks for peptide synthesis” abstract, Gescrinier et al. j

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