Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-12-19
2008-10-14
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252140, C514S269000, C544S123000, C544S295000, C544S319000
Reexamination Certificate
active
07435734
ABSTRACT:
N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula:are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R1, R2, R3and R4are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
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Crescenzi Benedetta
Gardelli Cristina
Muraglia Ester
Nizi Emanuela
Orvieto Federica
Heber Sheldon O.
Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
Rao Deepak
Walton Kenneth R.
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