N-substituted glutamic acid derivatives with interleukin-1 .beta

Details N-substituted glutamic acid derivatives with interleukin-1 .beta N-substituted glutamic acid derivatives with interleukin-1 .beta

1996-08-13

1998-04-28

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530330, 530331, A61K 3805, A61K 3806, A61K 3809

Patent

active

057444510

ABSTRACT:
The present invention relates to N-substituted derivatives of glutamic acid of pharmaceutical interest, to pharmaceutical compositions which include compounds of the invention and pharmaceutically acceptable carriers, to methods of their preparation, and to their use in purification of interleukin-1.beta. converting enzyme (ICE).

REFERENCES:
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Imoto, Masahiro; Kageyama, Shigeki; Kusumoto, Shoichi; Kohno, Morihiro; Matsumoto, Kensuke; Hashimoto, Shinjiro; Tohgo, Akiko; Shiba, TetsuoTi Synthesis and antitumor activity of N-acetylmuramyl-L-alanyl-D-isoglutamine 6-phosphate and its, 1986.
Rossi, Domenico; Romeo, Aurelio; Lucente, GinoTI Approach to the use of benzylpenicillinacylase for configurational correlations of amino compoundsSO J. Org. Chem. (1978), 43(13), 2576-81 C.
Miyamoto, Masashi; Kondo, Shinichi; Naganawa, Hiroshi; Maeda, Kenji; Ohno, Masaji; Umezawa, HamaoTI Structure and synthesis of neothramycinSO J. Antibiot. (1977), 30(4), 340-3 C.

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