Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-10-07
1986-12-30
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546194, 546210, 514318, 514326, 544335, 544242, A61K 31505, A61K 31445, C07D21168, C07D23902
Patent
active
046329250
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is ##STR2## the asterisk denotes the specific bonding orientation to the piperidine moiety; R.sub.2 is alkylene or --CO--(CH.sub.2).sub.n -- wherein n is 0 to 11; R.sub.3 and R.sub.4, independently, are hydrogen, halogen or lower alkoxy; and HET is pyridinyl, pyrimidinyl or imidazolyl, and salts thereof with pharmaceutically acceptable acids, are described. The compounds of formula I exhibit insulin lowering activity and are useful as antiobesity agents.
REFERENCES:
patent: 4076717 (1978-02-01), Kreider
Kierstead Richard W.
Mullin, Jr. John G.
Triscari Joseph
Hoffmann-La Roche Inc.
Isgro William G.
Jiles Henry R.
Leon Bernard S.
Saxe Jon S.
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