N-substituted benzothiophenesulfonamide derivatives

Details N-substituted benzothiophenesulfonamide derivatives N-substituted benzothiophenesulfonamide derivatives

2008-07-15

2008-07-15

Saeed, Kamal (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S051000

Reexamination Certificate

active

07399781

ABSTRACT:
The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

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Miyazaki, Mizuo et al, “Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models,” Pharmacology & Therapeutics (2006), vol. 112, pp. 668-676.
XP002308847, Pailer et al., Chemical Abstracts (1962).
Supplementary European Search Report for EP01967708 dated Dec. 3, 2004.

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