N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharma

Details N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharma N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharma

1985-10-01

1990-07-03

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514601, 540 1, 540362, 548577, 560 9, 560 10, 560 12, 560 13, 560 21, 560 45, 564 99, 564161, 564166, 564167, 564169, 564153, 564154, 564155, 564173, 564179, C07C23315, C07C23329, C07C23366, C07C23375

Patent

active

049391330

ABSTRACT:
The present invention relates to novel N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-.alpha.-oxo-benezene acetamide compounds pharmaceutical compositions, and methods of use for therefore for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.

REFERENCES:
patent: 3646199 (1972-02-01), Scheffenbaum et al.
patent: 4158063 (1979-06-01), Hitzel et al.
patent: 4562201 (1985-12-01), Stout et al.
patent: 4742083 (1985-09-01), Ritchey
Chem. Abstracts, vol. 84, No. 22, May 31, 1976, page 93, No. 155204s (c/o Fuji Photo Film, JP-A-75 161525, 12/27/75).
Chem. Abstracts, vol. 76, No. 5, Jan. 31, 1972, page 343, No. 24952g (c/o Nealey et al., J. Chem. Eng. Data 1971, 16(4), pp. 482-483).
Chem. Abstracts, vol. 86, No. 21, May 23, 1977, page 440, No. 155310a (c/o Kenji et al., Nippon Kagaku Kaishi, 1976, (12), 1899-903).
Mashevskaya et al., (Perm. Farm. Inst.), Izv Vyssh. Uchebn. Faved., Khem. Khim. Tekhnol. 1979, 22(11), pp. 1323-1326.
EPO Search Report with attachments.

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