N',N"-dialkylguanidino dipeptides

Details N',N"-dialkylguanidino dipeptides N',N"-dialkylguanidino dipeptides

1986-09-10

1988-08-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 548533, 548538, 546226, 546245, 540609, 540483, A61K 3743, C07K 506, C07D20700, C07D21106, C07D21160

Patent

active

047628219

ABSTRACT:
N',N"-dialkylguanidino dipeptides with angiotension converting enzyme (ACE) inhibiting activity are useful as antihypertensives. Proline and proline analogs are components of the dipeptides.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4470972 (1984-09-01), Gold et al.
patent: 4472380 (1984-09-01), Harris et al.
patent: 4500518 (1985-02-01), Gordon et al.
patent: 4587258 (1986-05-01), Gold et al.
U.S. Patent Application Ser. No. 06/905,827, filed 9/10/86, (Arzeno et al).
J. J. Nestor, Jr., et al., "Peptides-Structure and Function", Proc. Eighth Anes. Peptide Symposium, V. J. Hruby et al., Eds., Pierce Chem. Co., Rockford, IL, 1984, pp. 861-864.

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