Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-10-16
1992-05-12
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514416, 548472, 548507, A61K 3140, C07D20934, C07D20926
Patent
active
051128462
ABSTRACT:
The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective inhibitors of cyclooxygenase and 5-lipoxygenase.
REFERENCES:
patent: 4769387 (1988-09-01), Summers et al.
patent: 4873259 (1989-10-01), Summers, Jr. et al.
J. Org. Chem., vol. 54, No. 5, 1989, 1221-1223, A. O. Stewart et al.
J. Med. Chem., 1988, vol. 31, 3-5, J. B. Summers et al.
J. Med. Chem., 1987, 30, 574-580, J. B. Summers et al.
Belliotti Thomas R.
Cetenko Wiaczeslaw A.
Connor David T.
Flynn Daniel L.
Kostlan Catherine R.
Daignault Ronald A.
Lee Mary C.
Miltenberger Lenora
Warner-Lambert & Company
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