Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-01-22
1990-09-04
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514269, 544322, 544328, 544831, A61K 31505, A61K 31445, C07D23942
Patent
active
049545060
ABSTRACT:
This invention pertains to novel substituted N-heterocyclic-N-(4-piperidinyl)amides useful as analgesics and antagonists of opioids, wherein the compounds have the general formula: ##STR1## including optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:
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Youcheng, et al., Structural Modification of 4-N-Propionyl Group, etc. 1983, 7 pages, (Yaoxue Xuebo 18(8) 591-596.
Studies on Potent Analgesics, Youcheng et al. (3/81), 12 pages, article (Acta Pharmaceutica Sinica), vol. XVI, No. 3.
S. Grossman et al., Pyridin-Analoga Des Fentanyls (1978), 6 pages, article (Arch. Pharm. Weinheim).
Janssens et al., New Antihistiminic N-Heterocyclic 4-Piperidiamines (1985), 5 pages, (J. Med. Chem), vol. 28, No. 12, pp. 1925-1947.
Bagley Jerome R.
Spencer H. Kenneth
BOC, Inc.
Cassett Larry R.
Lee Mary C.
Richter J.
Swope R. Hain
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