N-heterocyclic derivatives as NOS inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S272000, C514S273000, C514S274000, C514S275000, C544S316000, C544S317000, C544S319000, C544S320000, C544S324000, C544S328000, C544S331000

Reexamination Certificate

active

06846829

ABSTRACT:
N-Heterocyclic derivatives of the formula (I):are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

REFERENCES:
patent: 5244865 (1993-09-01), Seltz et al.
patent: 5426110 (1995-06-01), Gossett et al.
patent: 5489591 (1996-02-01), Kobayashi et al.
patent: 5663334 (1997-09-01), Sheldrake et al.
patent: 6172005 (2001-01-01), Selby et al.
patent: 20020010190 (2002-01-01), Davey et al.
patent: 0 257 850 (1988-03-01), None
patent: 0 640 599 (1995-03-01), None
patent: WO9614842 (1996-05-01), None
patent: WO9614844 (1996-05-01), None
patent: WO9809960 (1998-03-01), None
Lee et al., Chemical Abstracts, vol. 125:114708, 1996.*
Lampe et al., Chemical Abstracts, vol. 121:83263, 1994.*
Shirakawa et al., Chemical Abstracts, vol. 61:61692, 1064.*
Feldman et al., “The Surprising Life of Nitric Oxide”,Chemical and Engineering News(1993) 26-38.
Del Corona et al., “Synthesis and in vitro study of platelet antiaggregant activity of 2(4)-imidazol-1-yl-4(2)-cycloalkylaminopyrimidines”,Eur. J. Med. Chem. (1991) 26(7):729-733.
Fujisawa et al., “Inducible Nitric Oxide Synthase in a Human Glioblastoma Cell Line”,J. Neurochem.(1995) 64(1):85-91.
Damiani et al., “Fluormetric Determination of Nitrite”Talanta(1986)33(8): 649-652.
Nathan, “Nitric oxide as a secretory product of mammalina cells”,FASEB Journal(1992) 6:3052:3064.
Lampe et al., “A Novel Rearrangement of 1-(2-Aminoaryl)imidazoles”,J. Heterocyclic Chem(1994) 31:287-291.

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