N-heterocyclic derivatives as NOS inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S328000, C544S331000

Reexamination Certificate

active

06841674

ABSTRACT:
N-Heterocyclic derivatives of the formula (I):are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

REFERENCES:
patent: 5244865 (1993-09-01), Seltz et al.
patent: 5426110 (1995-06-01), Gossett et al.
patent: 5489591 (1996-02-01), Kobayashi et al.
patent: 5663334 (1997-09-01), Sheldrake et al.
patent: 6172005 (2001-01-01), Selby et al.
patent: 20020010190 (2002-01-01), Davey et al.
patent: 0 257 850 (1988-03-01), None
patent: 0 640 599 (1995-03-01), None
patent: WO9614842 (1996-05-01), None
patent: WO9614844 (1996-05-01), None
patent: WO9809960 (1998-03-01), None
Fujii et al., Chemical Abstracts, vol. 127:220944, 1997.*
Ikeda et al., Chemical Abstracts, vol. 107:106167, 1987.*
Feldman et al., “The Suprising Life of Nitric Oxide”,Chemical and Engineering News(1993) 26-38.
Del Corona et al., “Synthesis and in vitro study of platelet antiaggregant activity of 2(4)-imidazol-1-yl-4(2)-cycloalkylaminopyrimidines”,Eur. J. Med. Chem. (1991) 26(7):729-733.
Fujisawa et al., “Inducible Nitric Oxide Synthase in a Human Glioblastoma Cell Line”,J. Neurochem.(1995) 64(1): 85-91.
Damiani et al., “Fluormetric Determination of Nitrite”Talanta(1986)33(8): 649-652.
Nathan, “Nitric oxide as a secretory product of mammalian cells”,FASEB Journal(1992) 6:3052:3064.
Lampe et al., “A Novel Rearrangement of 1-(2-Aminoaryl)imidazoles”,J. Heterocyclic Chem(1994) 31:287-291.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

N-heterocyclic derivatives as NOS inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-heterocyclic derivatives as NOS inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-heterocyclic derivatives as NOS inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3413529

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.