N-heterocyclic derivatives as NOS inhibitors

Details N-heterocyclic derivatives as NOS inhibitors N-heterocyclic derivatives as NOS inhibitors

2005-01-11

2005-01-11

Raymond, Richard L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S328000, C544S331000

Reexamination Certificate

active

06841674

ABSTRACT:
N-Heterocyclic derivatives of the formula (I):are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

REFERENCES:
patent: 5244865 (1993-09-01), Seltz et al.
patent: 5426110 (1995-06-01), Gossett et al.
patent: 5489591 (1996-02-01), Kobayashi et al.
patent: 5663334 (1997-09-01), Sheldrake et al.
patent: 6172005 (2001-01-01), Selby et al.
patent: 20020010190 (2002-01-01), Davey et al.
patent: 0 257 850 (1988-03-01), None
patent: 0 640 599 (1995-03-01), None
patent: WO9614842 (1996-05-01), None
patent: WO9614844 (1996-05-01), None
patent: WO9809960 (1998-03-01), None
Fujii et al., Chemical Abstracts, vol. 127:220944, 1997.*
Ikeda et al., Chemical Abstracts, vol. 107:106167, 1987.*
Feldman et al., “The Suprising Life of Nitric Oxide”,Chemical and Engineering News(1993) 26-38.
Del Corona et al., “Synthesis and in vitro study of platelet antiaggregant activity of 2(4)-imidazol-1-yl-4(2)-cycloalkylaminopyrimidines”,Eur. J. Med. Chem. (1991) 26(7):729-733.
Fujisawa et al., “Inducible Nitric Oxide Synthase in a Human Glioblastoma Cell Line”,J. Neurochem.(1995) 64(1): 85-91.
Damiani et al., “Fluormetric Determination of Nitrite”Talanta(1986)33(8): 649-652.
Nathan, “Nitric oxide as a secretory product of mammalian cells”,FASEB Journal(1992) 6:3052:3064.
Lampe et al., “A Novel Rearrangement of 1-(2-Aminoaryl)imidazoles”,J. Heterocyclic Chem(1994) 31:287-291.

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