Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-04-21
2000-08-15
Ulm, John
Drug, bio-affecting and body treating compositions
Lymphokine
514 2, 514 12, 930140, 530351, A61K 3819, A61K 3820, C07K 1453
Patent
active
061032247
ABSTRACT:
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
REFERENCES:
patent: 4230697 (1980-10-01), Nishida et al.
patent: 4275056 (1981-06-01), Takaku et al.
patent: 4342828 (1982-08-01), Takaku et al.
patent: 4432895 (1984-02-01), Tarnowski
patent: 4438032 (1984-03-01), Golde et al.
patent: 4482485 (1984-11-01), Funakoshi et al.
patent: 4485017 (1984-11-01), Tan et al.
patent: 4504586 (1985-03-01), Nicolson
patent: 4601978 (1986-07-01), Karin
patent: 4658018 (1987-04-01), Urdal et al.
patent: 4847201 (1989-07-01), Kawasaki et al.
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4868119 (1989-09-01), Clark et al.
patent: 4879227 (1989-11-01), Clark et al.
patent: 4929700 (1990-05-01), Halenbeck et al.
patent: 5093242 (1992-03-01), Bachmair
patent: 5104650 (1992-04-01), Ralph et al.
patent: 5171675 (1992-12-01), Cerretti et al.
patent: 5650297 (1997-07-01), Takahashi et al.
Tsunasawa et al., J. of Biol. Chem. (1985) 260:5382-91.
Dalboge et al., FEBS Letters (1990) 266:1-3.
Dorland's Illustrated Medical Dictionary, 24th Edition, W.B. Saunders Co., Philadelphia (1965) at p. 1485.
Yammushi et al, J. Biochem., v 109, 1991, pp. 404-409.
Ben-Bassat--J. Bacteriology, 169(2), 1987, pp. 751-757.
Metcalf et al. Blood, (1986) 67(2):257-267.
Clark et al. Science (1987) 236:1229-1237.
DeLarmarter et al. Nucleic Acids Res. (1987) 15(5):2389-2390.
Rajavashisth et al. PNAS(USA) (1987) 84:1157-1161.
Csejtey et al. Biochem. Biophys. Res. Comm. (1986) 138:238-245.
Strickler et al. BIOSIS (1984) No. 28054134.
Kriegler et al. Exp. Hematol. (1984) 12:844-849.
Biological Abstract No. 29103717 (1985) Biological Abstracts/RRM vol. 5 No. 9 Genet. Technol. News(US)--Hester.
Biological Abstract No. 29077739 (1985) Biological Abstracts/RRM vil. 5 No. 15 Genet. Eng. Lett.--Fishbein.
Ishizaka et al. Exp. Hematol. (1986) 14:1-8.
Motoyoshi et al. Blood (1978) 52:1012-1020.
Motoyoshi et al. Blood (1983) 62(3):685-688.
Warren et al. J. Immunol. (1985) 134(2):982-989.
Warren et al. J. Immunol. (1986) 137(7):2281-2285.
Ralph et al. Immunobiol. (1986) 172:194-204.
Nagata et al. Nature (1986) 319:415-418.
Nagata et al. J. EMBO (1986) 5(3):575-581.
Souza et al. Science (1986) 232:61-65.
Cantrell et al. PNAS(USA) (1985) 82:6250-6256.
Dexter,Nature (1984) 309:746.
Vadas et al., J. Immunol. (1983) 130:793.
Metcalf, Science (1985) 229:16-22.
Das et al., Blood (1981) 58:630.
Stanley et al., J. Biol. Chem. (1977) 252:4305.
Waheed et al., Blood (1982) 60:238.
Ben-Avram et al. PNAS (USA) (1985) 82:7801.
Das et al., J. Biol. Chem. (1982) 257:13679.
Wang et al., J. Cell Biochem. (1983) 21:263.
Waheed et al., Exp. Hemat. (1984) 12:434.
Wu et al. J. Biol. Chem. (1979) 254:6226.
Fojo et al., Biochemistry (1978) 17:3109.
Burgess et al., J. Biol. Chem. (1977) 252:1998.
Lusis et al., Blood (1981) 57:13.
Wu et al., Biochemistry (1980) 19:3846.
Gough et al., Nature (1984) 309:763-767.
Fung et al., Nature (1984) 307:233.
Yang et al., Cell (1986) 47:3-10.
Dorssers et al., Gene (1987).
Yokota et al., PNAS (USA) (1984) 81:1070-1074.
Wong et al. Science (1985) 228:810-815.
Lee et al., PNAS (USA) (1985) 82:4360-4363.
Kawasaki et al., Science (1985) 230:292-296.
Wong et al., Science (1987) 235:1504-1509.
Ladner et al., J. of EMBO (1987) 6:2693-2698.
Metcalf, D., J. Cell Physiol. (1970) 76:89.
Moore et al., Science (1984) 223:178.
Stanley, E.R., The Lymphokines (1981), Stewart W.E. et al., (eds) Humana Press, Clifton, N.J., pp. 102-132.
Byrne et al., Cell Biol. (1981) 91:848.
Fleit et al., J. Cell Physiol. (1981) 108:347.
Wing et al., J. Clin. Invest. (1982) 69:270.
Ralph et al., Cell. Immunol. (1983) 76:10.
Nogawa et al., Cell Immunol. (1980) 53:116.
Bolivar et al., Gene (1977) 2:95.
Chang et al., Nature (1977) 198:1056.
Goeddel et al., Nucleic Acids Res. (1980) 8:4057.
Shimatake et al., Nature (1981) 292:18.
Broach J.R., Meth. Enz. (1983) 101:307.
Stinchcomb et al., Nature (1979) 282:39.
Tschempe et al., Gene (1980) 10:157.
Clarke et al., Meth. Enz. (1983) 101:300.
Hess et al., J. Adv. Enzyme Reg. (1968) 7:149.
Holland et al., Biochemistry (1978) 17:4900.
Hitzeman et al., J. Biol. Chem. (1980) 255:2073.
Holland et al., J. Biol. Chem. (1981) 256:1385.
Broach et al., Gene (1978) 8:121.
Tissue Culture, Academic Press, Cruz and Patterson (eds.) (1973).
Fiers et al., Nature (1978) 273:113.
Depicker et al., J. Mol. Appl. Gen. (1982) 1:561.
Miller et al., Genetic Engineering (1986) Setlow et al. (eds), Plenum Publishing, vol. 8, pp. 277-297.
Cohen, S.N., PNAS (USA) (1972) 69:2110.
Shaw et al., Gene (1983) 23:315.
Graham et al., Virology (1978) 52:546.
Van Solingen et al., J. Bact. (1977) 130:946.
Hsiao et al., PNAS (USA) (1979) 76:3829.
Maniatis et al., Molecular Cloning (1982) Cold Spring Harbor Press, pp. 202-203.
Bailey et al., Anal. Biochem. (1976) 70:75-85.
Sehgal et al., Nature (1980) 288:95-97.
Methods in Enzymology (1980) 65:499-560.
Matteucci et al., J. Am. Chem. Sos. (1981) 103:3185-3191.
Clewell et al., PNAS (USA) (1969) 62:1159.
Clewell D.B., J. Bacteriol (1972) 110:667.
Sanger et al., PNAS (USA) (1977) 74:5463.
Messing et al., Nucleic Acids Res. (1981) 9:309.
Maxam et al., Methods in Enzymology (1980) 65:499.
Fleit et al., J. Cell. Physiol. (1981) 108:347.
Ralph et al., Cell Immunol. (1987) 105:270-279.
Ralph et al., Cell Immunol. (1983) 76:10.
Stanley, E.R., Methods in Enzymology (1985) 116:564.
Gluzman Y., Cell (1981) 23:175.
Ringold G., J. Mol. App. Genet. (1982) 1:165.
Berger et al., Biochemistry (1979) 18:5143.
Aviv et al., PNAS (USA) (1972) 69:1408-1412.
Moore et al., J. Immunol. (1983) 131:2374.
Prystowsky et al., DNA Cloning Techniques: A Practical Approach (IRL Press, Oxford 1984) Glover, D. (ed.).
Okayama et al., Mol. Cell. Biol. (1983) 3:280-289.
Wang A.M. et al., Science (1985) 228:149.
Stanley et al., J. Lab. Clin. Med. (1972) 79:657.
Gorman et al., Science (1983) 221:551-553.
Maxam et al., Methods in Enzymology (1980) 68:521, Academic Press.
Sherman et al., Bio. Essays (1985) 3(1):27-31.
Gonda et al. J. of Biological Chem. (1989) 264:16700-16712.
Cerretti et al., Mol. Immunol. (1988) 25:761-770.
Leatherbarrow et al., Protein Engineering (1986) 1:7-16.
Dalboge, et al., "Cloning And Expression of an Interleukin-1.beta. Precursor and Its Conversion to Interleukin-1.beta.", FEB 246(1):89-93 (1989).
Dalboge, et al., "A Novel Enzymatic Method For Production of Authentic hGH From An Escherichia coli Produced hGH-Precursor", Biotechnology, 5:161-164 (1987).
Kunitani, et al., "Reversed-Phase Chromatography of Interleukin-2 Muteins", Journal of Chromatography, 359:391-402 (1986).
Lahm, et al., "Characterization of Recombinant Human Interleukin-2 With Micromethods", Journal of Chromatography, 326:357-361 (1985).
Yamagishi, et al., "Determination of the Minimum Polypeptide Molecule With the Biological Activity of Human Tumor Necrosis Factor", Int'l. J. of Immunopathology and Pharm., 2 (3):191-202 (1985).
Coyne Mazie Yee
Halenbeck Robert F.
Kawasaki Ernest S.
Koths Kirston E.
Ladner Martha B.
Blackburn Robert P.
Chiron Corporation
Morley Kimberlin L.
Pochopien Donald J.
Saoud Christine
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