Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1977-09-15
1979-04-17
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
546200, 546272, 2603068R, 2603068D, 2603068A, 260307H, 260307G, 260308D, 260308R, 26032625, 4242485, 424250, 424263, 424267, 424269, 424270, 424272, 424273R, 542416, 544144, 544238, 544282, 544351, 548336, C07D48704, A16K 3140
Patent
active
041501454
ABSTRACT:
Disclosed are N-alkylated derivatives of thienamycin sulfoxide (I, n=1) and sulfone (I, n=2): ##STR1## wherein n=1 or 2; and R.sup.5, R.sup.6, and R.sup.7 are, inter alia, hydrogen or alkyl. Such compounds the their pharmaceutically acceptable O- and carboxyl- derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 3862181 (1975-01-01), Davis et al.
patent: 3950357 (1976-04-01), Rahan et al.
patent: 4000129 (1976-12-01), Verwey et al.
patent: 4000161 (1976-12-01), Geogelman et al.
patent: 4022773 (1977-05-01), Ishimaru
Brown et al.; J. C. S. Chem. Comm. (1977) p. 523.
Maeda et al.; J. Antibiotics vol. 30 (1977) p. 770.
Fieser et al.; Advanced Organic Chemistry p. 313 (1961).
Christensen Burton G.
Firestone Raymond A.
Leanza William J.
Arnom James A.
Daus Donald G.
Lee Mary
Levitt Julian S.
Mahon Frank M.
LandOfFree
N-alkylated derivatives of thienamycin sulfoxide and sulfone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-alkylated derivatives of thienamycin sulfoxide and sulfone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-alkylated derivatives of thienamycin sulfoxide and sulfone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1262270