Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2007-07-17
2007-07-17
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S630000
Reexamination Certificate
active
10949322
ABSTRACT:
The present invention relates to the use of N-acylvanillinamide derivatives capable of activating the peripheral receptor CB1 of cannabinoids. In particular, the present invention relates to the use of compounds of general formula (I)in which the meanings of R, R1, R3and Y are as defined in the description, for the preparation of a medicinal product which is capable of activating the peripheral receptor CB1 of cannabinoids.
REFERENCES:
patent: 0613879 (1994-09-01), None
patent: WO 96/18391 (1996-06-01), None
Morre, D.J. et al, Eur. J. Cancer, 1996, 32A(11), 1995-2003.
West, A.R. Solid State Chemistry and its Applications, Wiley, 1988, pp. 358 and 365.
Morre et al European Journal of Cancer, 1996, 32A(11), 1995-2003.
Melck D et al.: “Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors.” Biochemical and Biophysical Research Communications, Aug. 1999, 262 (1) 275-84.
Di Marzo V et al.: “Interactions between synthetic vanilloids and the endogenous cannabinoid system.” FEBS Letters, Oct. 1998, 436 (3) 449-54.
Dray A.: “Neuropharmacological Mechanisms of Capsaicin and Related Substances” Biochemical Pharmacology, GB, Pergamon, Oxford, vol. 44, No. 4, Aug. 1992, pp. 611-61.
Winter J. et al.: “Characterization of resiniferatoxin binding sites on sensory neurons: Co-regulation of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia.” NEUROSCIENCE, (1993) 57/3 (747-757).
Morre D J et al.: “Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines.” European Journal of Cancer, (Oct. 1996) 32A (11) 1995-2003.
Database WPI Section Ch, Week 199318 Derwent Publications Ltd., London, GB; AN1993-149228 & JP05 086086 (Ogawa Koryo KK), Apr. 1993
Database WPI Section Ch, Week 199815 Derwent Publications Ltd., London, GB; AN1998-162352 & JP10 025237 (Kanebo Ltd), Jan. 1998.
Janusz, J.M. et al “Vanilloids. Analogs of Capsaicin with Antinociceptive and Antininflammatory Activity”, Journal of Medicinal Chemistry, 1993, 36, 2592-2604.
Bisogno Tiziana
De Petrocellis Luciano
Della Valle Francesco
Di Marzo Vincenzo
Marcolongo Gabriele
Consiglio Nazionale Delle Richerche
Innovet Italia S.R.L.
Jiang Shaojia Anna
Krishnan Ganapathy
LandOfFree
N-acylvanillinamide derivatives capable of activating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-acylvanillinamide derivatives capable of activating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-acylvanillinamide derivatives capable of activating... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3784609