N-Acyl-muramyl peptide derivatives having anti-infectious infect

Details N-Acyl-muramyl peptide derivatives having anti-infectious infect N-Acyl-muramyl peptide derivatives having anti-infectious infect

1977-11-01

1981-06-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

042725240

ABSTRACT:
The invention relates to a new method for increasing the resistance of the organism to pathogenic germs and to compositions to carry out said method.
In this method, one administers an effective dose of N-acetyl-muramyl-L-alanyl-D-isoglutamine or analogs responding to the formula ##STR1## wherein R.sub.1 is OH or NH.sub.2, R.sub.2 is OH, NH.sub.2 or a peptidic residue containing from 1 to 6 aminoacids,
with the proviso that R.sub.1 and R.sub.2 are not simultaneously NH.sub.2.

REFERENCES:
patent: 4082735 (1978-04-01), Jones et al.
patent: 4082736 (1978-04-01), Jones et al.
F. Ellviz, et al., Biochem. and Biophys. Res. Commun., 59, 1974, pp. 1317-1325.
Ghuysen, et al., Bact. Membranes and Walls, 1973, pp. 39-41.
Chaturvedi, J. Med. Chem., 9, 1966, pp. 971-973.
Kostani, et al., Sympos. Internat'l. or Bact. Immunostimulants, 1973, p. 8.
Lamzelotti, et al., J. Am. Chem. Soc., 86, 1964.
Kotani, et al., Biken J., 13, 105-111, 1975.
Adam, et al., Biochem. and Biophys. Res. Commun., 72, 1976, pp. 339-346.
Chem. Abst., 87, 1977, pp. 199018m, 118075c, 51519e.

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