N-acyl-4-phenyl-pyrrolidin-2-ones and method for preparing

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514423, 514340, 514408, 546268, 546275, 546281, 548530, 548539, 548540, A61K 31455, A61K 3140, C07D40102, C07D40302

Patent

active

054419735

ABSTRACT:
The invention is directed to N-acetyl-4-phenyl-pyrrolidin-2-ones, which, because of their pronounced cerebroprotective effect in human medicine, can be used for the prophylaxis and treatment of cerebral functional disorders. Pursuant to the invention, these compounds are synthesized by reacting 4-phenyl-pyrrolidin-2-ones with a reactive derivative of a carboxylic acid, or by cyclizing N-acylaminobutyric acid derivatives.

REFERENCES:
patent: 4012495 (1977-03-01), Schmiechen et al.
patent: 5227395 (1993-07-01), Komatsu et al.

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