N-(2-sulfatoethyl)piperazine sulfate and its preparation

Details N-(2-sulfatoethyl)piperazine sulfate and its preparation N-(2-sulfatoethyl)piperazine sulfate and its preparation

1995-03-15

1996-10-08

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544401, C07D295108

Patent

active

055632718

ABSTRACT:
Preparation of N-(2-sulfatoethyl)piperazine sulfate by reacting N-(2-hydroxyethyl)piperazine in a mixture of high- or relatively high-percentage sulfuric acid and oleum or chlorosulfonic acid at temperatures of about 80.degree. C. to about 250.degree. C., introducing the sulfation mixture formed into a water-miscible aliphatic alcohol and isolating the N-(2-sulfatoethyl)piperazine sulfate formed.

REFERENCES:
patent: 3194826 (1965-07-01), Goldstein
Tomalia et al, J. Het. Chem. 9, pp. 891-894 (1972).
Organic Functional Group Preparations by Stanley R. Sandler and Wolf Karo, vol. III pp. 116-124, (1972).
Research Techniques in Organic Chemistry by Robert B. Bates and John P. Schaefer, pp. 50, 51, 55 (1971).
J. Amer. Chem. Soc., Bd. 75, 1953, "The Synthesis and Alkaline Decomposition of gamma-Amino-propylsulfuric Acid", pp. 2505-2506.
J. Amer. Chem. Soc., Bd. 57, 1935, "The Preparation of Ethylene Imine from Monoethanolamine", p. 2328.

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