N- (2-aminophenyl) benzamide derivative having urea structure

Details N- (2-aminophenyl) benzamide derivative having urea structure N- (2-aminophenyl) benzamide derivative having urea structure

2007-12-26

2011-12-13

Kosar, Andrew D (Department: 1622)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S237800, C514S424000, C514S254110, C514S596000, C544S131000, C544S165000, C544S377000

Reexamination Certificate

active

08076332

ABSTRACT:
The present invention relates to a study on the synthesis of a novel N-(2-aminophenyl)benzamide derivative having an urea structure and represented by the general formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork cells and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pressure. In the formula, R1and R2represent a hydrogen atom, a lower alkyl group, or the like; R3represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, or the like; R4and R5represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, or the like; X represents a lower alkylene group or the like; Y represents a single bond, a lower alkylene group, or the like; l and m represent 0, 1, 2, or the like.

REFERENCES:
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patent: 10-152462 (1997-09-01), None
patent: 10-152462 (1998-06-01), None
patent: WO 97/30701 (1997-08-01), None
patent: WO 00/09162 (2000-02-01), None
Javvadhi et al. (Kathmandu University Medical Journal (2005) vol. 3, No. 3, Issue 11, 217-221.)

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