Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-10
1995-12-19
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 221, 536 231, 536 2432, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
054767687
ABSTRACT:
Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase .beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.
REFERENCES:
Redmond et al., (1960), "A bacteriophage specific for Mycobacterium tuberculosis, varieties hominis and bovis", Am. Rev. Resp. Dis. 82(6):781-786.
Redmond et al., (1963), "Spotting method of phage typing mycobacteria", Am. Rev. Resp. Dis. 87:257-263.
Ross et al., (1991), "Differentiation of Mycobacterium tuberculosis strains by use of a nonradioactive southern blot hybridization method", J. Inf. Dis. 163:904-907.
Jones, (1988), "Bacteriophage typing of Mycobacterium tuberculosis cultures from incidents of suspected laboratory cross contamination" Tubercle 69:43-46.
Saunders, (1995), "State of the art: typing Mycobacterium tuberculosis", J. Hosp. Inf. 29::169-176.
Sula et al., (1979), "Accidental contamination of diagnostic cultures of mycobacteria and phage identification of the contaminating strain", Tubercle 60:159-162.
Jacobs et al., (1989), "Mycobacteriophage vector systems", Rev. Inf. Dis. 11(2):S404-S410.
Grange et al., (1978), "Host-phage relationships in the genus mycobacterium and their clinical significance", Tubercle 59:203-225.
Beyer, Jr. Wayne F.
Dickson Julie A.
Hamilton Paul T.
Little Michael C.
Pearson Robert E.
Becton Dickinson and Company
Fredman Jeffrey N.
Fugit Donna R.
Jones W. Gary
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