Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-05-19
1991-10-15
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514247, 514277, 514307, 514311, 514315, 514374, 514378, 514399, A61K 31415, A61K 31425
Patent
active
050575309
ABSTRACT:
Glycerol derivatives of the formula ##STR1## wherein one of the residues R.sup.1, R.sup.2 and R.sup.3 is a group U of the formula OY.sup.1 or --X.sup.1 --CO--(A.sup.1).sub.n --Z.sup.1, another residue is a group V of the formula OY.sup.2 or --X.sup.2 --CO--(A.sup.2).sub.p --Z.sup.2, and the remaining residue is a group W of the formula --X.sup.3 T--(C.sub.2-6 -alkylene)-N.sup.+ R A.sup.- in which one of X.sup.1, X.sup.2 and X.sup.3 is oxygen or NQ.sup.1 and the other two are oxygen and the remaining symbols have the significance given below, and their hydrates are described and are prepared by introducing or generating the residues R.sup.1, R.sup.2 and R.sup.3 in corresponding glycerol derivatives.
The compounds of formula I are active as inhibitors of blood platelet activating factor or as inhibitors of the growth of tumors.
REFERENCES:
patent: 4731373 (1988-03-01), Barner et al.
Barner Richard
Burri Kaspar
Cassal Jean-Marie
Hadvary Paul
Hirth Georges
Ciambrone Coletti Ellen
Gerstl Robert
Gould George M.
Hoffmann-La Roche Inc.
Leon Bernard S.
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