Mycobacterial inhibitors

Details Mycobacterial inhibitors Mycobacterial inhibitors

2011-03-08

2011-03-08

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S611000, C546S159000, C546S167000

Reexamination Certificate

active

07902225

ABSTRACT:
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib)the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases. In particular, compounds are claimed in which, independently from each other, R1is halo; p=1; R2is optionally substituted alkyloxy, alkyl, Ar, Het, or a radical of formulaR3is optionally substituted Ar or Het; q=1, R4and R5each independently are alkyl; R6is hydrogen or a radical of formular is equal to 0 or 1 and R7is hydrogen or Ar. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.

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