Muteins of fibroblast growth factor 21

Details Muteins of fibroblast growth factor 21 Muteins of fibroblast growth factor 21

2004-12-01

2009-02-17

Saoud, Christine J (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S399000

Reexamination Certificate

active

07491697

ABSTRACT:
The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

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Nishimura, et al., “Identification of a Novel FGF, FGF-21, Preferentially Expressed in the Liver”, Biochimica et Biophysica Acta, 1492 (2000), 203-206.

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