Muscarinic receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514452, 514466, 514471, 514603, 514616, 514620, A61K 3144, A61K 31335, A61K 3118, A61K 3116

Patent

active

052198715

ABSTRACT:
Compounds of the formula I ##STR1## wherein X, Y and v are as defined below, novel intermediates used in their synthesis, and the pharmaceutically acceptable salts of such compounds and intermediates. The compounds of formula I and the novel intermediates used in their synthesis are muscarinic receptor antagonists that are selected for smooth muscle muscarinic sites and are useful in the prevention and treatment of diseases associated with altered motility or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, aesophageal achalasia, and chronic obstructive airways disease.

REFERENCES:
patent: 4335122 (1982-06-01), McFadden et al.
Chemical Abstracts, 70(19), p. 293, Abstract No. 87390u (May 12, 1969).
Casy et al., J. Pharm. and Pharmacol., 19, 17-24 (1967).
Gualtieri et al., J. Med. Chem., 28, 1621-28 (1985).

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