Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2005-04-26
2005-04-26
Le, Long (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
C427S002100, C427S002110, C427S002120, C427S002130, C427S008000, C427S207100, C427S256000, C427S299000, C427S304000, C427S331000, C427S402000, C427S404000, C427S414000, C427S419100, C427S419500, C435S004000, C435S007100, C435S007920, C435S174000, C435S176000, C435S177000, C435S178000, C435S179000, C435S180000, C435S183000, C435S287100, C435S287200, C435S287700, C435S287800, C435S287900, C435S815000, C435S961000, C435S969000, C436S524000, C436S528000, C436S529000, C436S530000, C436S819000, C436S823000
Reexamination Certificate
active
06884628
ABSTRACT:
Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte. The multifunctional copolymer coatings typically include brush copolymers based on a polycationic or polyanionic (jointly referred to herein as ‘polyionic’) backbone with side chains that control interaction with the environment, such as poly(ethylene glycol) or poly(ethylene oxide)-based side chains that decrease cellular adhesion, and analyte-specific side chains. They can be used to pattern the surfaces into non-adhesive and specifically adhesive areas by applications of known techniques such as microfluidic or contact printing techniques.
REFERENCES:
patent: 4822867 (1989-04-01), Erhan
patent: 4886836 (1989-12-01), Gsell et al.
patent: 5250613 (1993-10-01), Bergstrom et al.
patent: 5330911 (1994-07-01), Hubbell et al.
patent: 5344455 (1994-09-01), Keogh et al.
patent: 5414075 (1995-05-01), Swan et al.
patent: 5459054 (1995-10-01), Skjak-Braek et al.
patent: 5462990 (1995-10-01), Hubbell et al.
patent: 5470731 (1995-11-01), Cochrum
patent: 5507804 (1996-04-01), Llanos
patent: 5512492 (1996-04-01), Herron et al.
patent: 5543326 (1996-08-01), Heller et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5578442 (1996-11-01), Desai et al.
patent: 5626863 (1997-05-01), Hubbell et al.
patent: 5627233 (1997-05-01), Hubbell et al.
patent: 5629213 (1997-05-01), Kornguth et al.
patent: 5658622 (1997-08-01), Berlin et al.
patent: 5661025 (1997-08-01), Szoka, Jr. et al.
patent: 5711915 (1998-01-01), Siegmund et al.
patent: 5776747 (1998-07-01), Schinstine et al.
patent: 5866322 (1999-02-01), Jou et al.
patent: 5916585 (1999-06-01), Cook et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 6093558 (2000-07-01), Seed et al.
patent: 6121027 (2000-09-01), Clapper et al.
patent: 6207749 (2001-03-01), Mayes et al.
patent: 6235340 (2001-05-01), Lee et al.
patent: 6248127 (2001-06-01), Shah et al.
patent: 6258870 (2001-07-01), Hubbell et al.
patent: 6265016 (2001-07-01), Hostettler et al.
patent: 6284503 (2001-09-01), Caldwell et al.
patent: 6287558 (2001-09-01), Lanza et al.
patent: 6291216 (2001-09-01), Muller et al.
patent: 6303136 (2001-10-01), Li et al.
patent: 6303179 (2001-10-01), Koulik et al.
patent: 6306243 (2001-10-01), Clark et al.
patent: 6306659 (2001-10-01), Parce et al.
patent: 6348322 (2002-02-01), Strittmatter
patent: 0 561 239 (1993-09-01), None
patent: WO 9206678 (1992-04-01), None
patent: WO 9307298 (1993-04-01), None
patent: WO 9324076 (1993-12-01), None
patent: WO 9427137 (1994-11-01), None
patent: WO-9846351 (1998-10-01), None
patent: WO 9847948 (1998-10-01), None
patent: WO 9847948 (1998-10-01), None
Humphries et al. The use of graft copolymers to inhibit the adhesion of bacteria to solid surfaces. FEMS Microbiology Ecology. (1987) vol. 45, pp. 297-304.*
Arnold & Rechnitz, “Selectivity enhancement of a tissue-based adenosine-sensing membrane electrode,”Anal. Chem.53(3):515-8 (1981).
Borenfreund, “Comparisons of two in vitro cytotoxicity assays—the neutral reds (NR) and tetrazolium MTT tests,”Toxic. In Vitro2(1):1-6 (1988).
Boyan, et al., “Effect of titanium surface characteristics on chondrocytes and osteoblasts in vitro,”Cell. Mater.5(4):323-35 (1995).
Burmeister, et al., “Application of total internal reflection fluorescence microscopy to study cell adhesion to biomaterials,”Biomaterials19(4-5):307-25 (1998).
Chittur, “Surface techniques to examine the biomaterial-host interface: an introduction to the papers,”Biomaterials19(4-5):301-5 (1998).
Divies, “Remarks on ethanol oxidation by an “Acetobacter xylinum” microbial electrode,”Ann. Microbiol.126(2):175-86 (1975).
Elbert & Hubbell, “Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers,”Chem. Biol.5(3):177-83 (1998).
Etcheverry, et al., “Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture,”Arch. Biochem. Biophys.338(1):7-14 (1997).
Fredriksson, et al., “The piezoelectric quartz crystal mass and dissipation sensor: A means of studying cell adhesion,”Langmuir14:248-251 (1998).
Honig, et al., “Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures,”J. Cell. Biol.103(1):171-87 (1986).
Kodama,et al., Establishment of a clonal osteogenic cell line from newborn mouse calvaria,Jpn. J. Oral Biol.23:899-901 (1981).
Labarca, et al., “A simple, rapid, and sensitive DNA assay procedure,”Anal. Biochem.102(2):344-52 (1980).
Luegmayr, et al., “Effects of triiodothyronine on morphology, growth behavior, and the actin cytoskeleton in mouse osteoblastic cells (MC3T3-E1),”Bone.18(6):591-9 (1996).
Macholan & Schanel, “Mushroom tissue-based biocatalytic electrode for determining phenols,”Biologia39(12):1191-1197 (1984).
Mackie, et al., “Modulation of osteoblast behaviour by tenascin,”J. Cell. Sci.109 ( Pt 6):1597-604 (1996).
Massia & Hubbell, “Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1,”J. Biol. Chem.267(20):14019-26 (1992).
McConnell, et al., “The cytosensor microphysiometer: biological applications of silicon technology,”Science257(5078):1906-12 (1992).
McKay, et al., “Interactions of orthopaedic metals with an immortalized rat osteoblast cell line,”Biomaterials.17(13):1339-44 (1996).
Moreau, et al., “Free radicals and side products released during methylmethacrylate polymerization are cytotoxic for osteoblastic cells,”J. Biomed. Mater. Res.40(1):124-31 (1998).
Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,”J. Immunol. Methods.65(1-2):55-63 (1983).
Mulchandini, et al., “Biosensor for direct determination of organophosphate nerve agents using recombinantEscherichia coliwith surface-expressed organophosphorus hydrolase. 1. Potentiometric microbial electrode,”Anal. Chem.70(19):4140-5 (1998).
Ragnarson, et al., “Labeling with fluorescent carbocyanine dyes of cultured endothelial and smooth muscle cells by growth in dye-containing medium,”Histochemistry.97(4):329-33 (1992).
Ramsden, et al., “Optical method for measurement of number and shape of attached cells in real time,”Cytometry19(2):97-102 (1995).
Ramsden, Review of new experimental techniques for investigating random sequential adsorption,Journal of Statistical Physics73 (5/6):853-877 (1993).
Rechnitz, et al., “Glutamine-selective membrane electrode that uses living bacterial cells,”Science199(4327):440-1 (1978).
Rodahl, et al., “Simultaneous frequency and dissipation factor QCM measurements of bimolecular adsorption and cell adhesion,”Faraday Discuss107:229-246 (1997).
Sudo, et al. “In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria,”J. Cell. Biol.96(1):191-8 (1983).
Yamamoto, “Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells,”J. Biomed
Elbert Donald L.
Finken Stephanie
Hofer Rolf
Hubbell Jeffrey A.
Ruiz-Taylor Laurence
Eidgenossische Technische Hochschule Zurich
Le Long
Pabst Patent Group LLP
Padmanabhan Kartic
Universitat Zurich
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