Multidrug resistance inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514649, A01N 3302

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active

060110694

ABSTRACT:
There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein n is an integer of 5 to 12,

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patent: 4723008 (1988-02-01), Tahara et al.
Patent Abstracts of Japan, vol. 11, No. 30, (C-400), Jan. 29, 1987, JP 61 200913, Sep. 5, 1986.
Journal National Cancer Institute, vol. 76, No. 5, pp. 947-953, May 1986, Teruhito Yamaguchi, et al., "Overcoming Drug Resistance in Cancer Cells with Synthetic Isoprenoids".
Takashi Tsuruo, et al. "Overcoming of Vincristine Resistance in P388 Leukemia in Vivo and in Vitro through Enhanced Cytotoxicity of Vincristine and Vinblastine by Verapamil", Cancer Research, vol. 41, (pp. 1967-1972), May 1981.
Carol O. Cardarelli, et al. "Differential Effects of P-Glycoprotein Inhibitors on NIH3T3 Cells Transfected with Wild-Type (G185) or Mutant (V185) Multidrug Transporters", Cancer Research, vol. 55, (pp. 1086-1091), Mar. 1, 1995.

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