Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-10-13
1995-01-31
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546133, 546137, C07D45302, A61K 31435
Patent
active
053859120
ABSTRACT:
This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
The compounds of this invention are described by the formula ##STR1## where Ar I is phenylene or naphthylene, Ar II is phenyl or naphthyl and A is 1-azabicyclo[2.2.2]octan-3-yl.
REFERENCES:
patent: 4203989 (1980-05-01), Yen et al.
patent: 4350518 (1982-09-01), Sauter et al.
patent: 4355166 (1982-10-01), Reiner
patent: 4631287 (1986-12-01), Chakraborty et al.
patent: 4826838 (1989-05-01), Richardson et al.
patent: 4839369 (1989-06-01), Youssefyeh et al.
Poulter, C. D., et al., "Squalene Synthetase. Inhibition by an Ammonium Analogue of a Carbocationic Intermediate in the Conversion of Presqualene Pyrophosphate to Squalene," J. Am. Chem. Soc., vol. 104, No. 25, pp. 7376-7378 (1982).
Poulter, C. D., et al., "Squalene Synthetase. Inibition by Ammonium Analogues of Carbocationic Intermediates in the Conversion of Presqualene Diphosphate to Squalene," J. Am. Chem. Soc., vol. III, No. 10, pp. 3734-3739 (1989).
Biller, S. A., et al., "Isoprenoid (Phosphenylmethyl)-phosphonates as Inhibitors of Squalene Synthetase," J. Med. Chem., vol. 31, No. 10, pp. 1869-1871 (1988).
Amin Dilip
Morris Robert L.
Neuenschwander Kent
Scotese Anthony C.
Kilby Scalzo Catherine S.
Nicholson James A.
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Richter Johann
LandOfFree
Multicyclic tertiary amine polyaromatic squalene synthase inhibi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multicyclic tertiary amine polyaromatic squalene synthase inhibi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multicyclic tertiary amine polyaromatic squalene synthase inhibi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1102383