Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1994-12-12
1996-07-02
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
204400, 204403, 422 8201, 422 8202, 435 71, 435 72, 4352871, 4352872, 436518, 436524, 436525, 436527, 436806, 436809, G01N 33543, G01N 2722
Patent
active
055321283
ABSTRACT:
A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
REFERENCES:
patent: 4072576 (1978-02-01), Arwin et al.
patent: 4098645 (1978-07-01), Hartdegen et al.
patent: 4293310 (1981-10-01), Weber
patent: 4414323 (1983-11-01), Masuda
patent: 4414325 (1983-11-01), Masuda et al.
patent: 4728882 (1988-03-01), Stanbro et al.
patent: 4769121 (1988-09-01), Newman
patent: 4786600 (1988-11-01), Kramer et al.
patent: 4822566 (1989-04-01), Newman
patent: 4935207 (1990-06-01), Stanbro et al.
patent: 4938742 (1990-07-01), Smits
patent: 4963245 (1990-10-01), Weetall
patent: 5001051 (1991-03-01), Miller et al.
patent: 5063081 (1991-11-01), Cozzette et al.
patent: 5064754 (1991-11-01), Mills
patent: 5071733 (1991-12-01), Uekita et al.
patent: 5082627 (1992-01-01), Stanbro
patent: 5164319 (1992-11-01), Hafeman et al.
patent: 5187096 (1993-02-01), Giaever et al.
patent: 5194133 (1993-03-01), Clark et al.
"A Method for DNA Sequencing by Hybridization With Oligonucleotide Matrix", DNA Sequence--J. DNA Sequencing and Mapping, vol. 1, 1991, pp. 375-388.
"Genetic Analysis of Amplified DNA with Immobilized Sequence-Specific Oligonucleotide Probes", Proc. Natl. Acad. Sci. USA, vol. 86, Aug. 1989, pp. 6230-6234.
"Use of Thiol-Terminal Silanes and Heterobifunctional Crosslinkers for Immobilization of Antibodies on Silica Surfaces", Analytical Biochemistry 178, 1989, pp. 408-413.
"Immobilization of Acetylcholinesterase on Solid Surfaces; Chemistry and Activity Studies", Sensors and Actuators, B. 3, 1991, pp. 311-337.
"Covalent Immobilization of DNA onto Polystyrene Microwells: The Molecules Are Only Bound at the 5'End", Analytical Biochemistry 198, 1991, pp. 138-142.
"A Sub-Micron Particle Filter in Silicon", Sensors and Actuators, A21-A23, 1990, pp. 904-907.
"Dielectric Dispersion of DNA", by Shiro Takashima, Journal of Molecular Biol., Feb. 13, 1963, 7 pp. 455-467.
"A 1024-Element High-Performance Silicon Tactile Imager", Suzuki et al., IEDM 88 1983 IEEE, pp. 674-677.
"Micro-Diaphragm Pressure Sensor", Sugiyama et al., IEDM 86, 1986 IEEE, pp. 184-187.
"Silicon Pressure Sensor Based on a Resonating Element", Buser et al, Sensors and Actuators A, 25-27 (1991) Elsevier Sequoia, The Netherlands, pp. 717-722.
"Q-Factor and Frequency Shift of Resonating Silicon Diaphragms in Air", Prak et al., Sensors and Actuators A, (1991) Elsevier Sequoia/The Netherlands, pp. 691-698.
"A Digital Optically Multiplexed Charge Coupled Device (CCD) Based Deoxyribonucleic Acid (DNA) Sequence Header", Craine et al., SPIE, vol. 914 Medical Imaging II, (1988).
"Biotinyl and Phosphotyrosinyl Phosphoramidite Derivatives Useful in the Incorporation of Multiple Reporter Groups on Synthetic Oligonucleotides" Misiura et al, 1990 Oxford University Press, Nucleic Acids Research, vo. 18, No. 15, pp. 4345-4354.
Sensitive Detection Systems, "Chemiluminescent and Bioluminescent Techniques", L. J. Kricka, Clin. Chem. 37/9, (1991) pp. 1472-1481.
"Nonradioactive Nucleic Acid Detection by Enhanced Chemiluminescences Using Probes Directly Labeled with Horseradish Peroxidase", Pollard-Knight et al., Analytical Biochemistry 195 (1990), pp. 84-89.
"Multiwavelenght Fluorescence Detectino for DNA Sequencing Using Capillary Electrophoresis", Oxford University Press, Nucleic Acids Research, vol. 19, No. 18, pp. 4955-4962.
"Imaging of Fluorescent and Chemiluminescent DNA Hybrids Using a 2-D CCD Camera", Karger et al., SPIE vol. 1206, New Technologies in Cytometry and Molecular Biology (1990), pp. 78-89.
Product Review, Nature, vol. 329 (Oct. 8, 1987) "Biosensors emerge from the laboratory", J. Briggs, pp. 565.
"Sub-Femtomole Quantitation of Proteins with Threshold.RTM., for the Biopharmaceutical Industry", Briggs et al., BioTechniques, vol. 9, No. 5 (1990) pp. 1-8.
"A Swept-Frequency Magnitude Method for the Dielectric Characterization of Chemical and Biological Systems", Hollis et al., Jul. 1980 IEEE Transactions And Microwave Theory And Techiques, vol. MTT-28, No. 7, pp. 791-801.
"Two-Dimensional Spatial Light Modulators: A Tutorial", Neff et al., IEEE, vol. 78, No. 5.
"Deformable-Mirror Spatial Light Modulators", Hornbeck et al., SPIE Critical Reviews Series vol. 1150, p. 86.
A proposal sent by Houston Advanced Research Center (HARC) to the National Institutes of Health in Jul. 1991. This Material describes the overall background and approaches for the fabrication of geo-sensors that were envisioned by HARC at that time.
Halliday et al, Physics, New York, John Wiley & Sons, 1978, p. 658.
Beattie Kenneth L.
Eggers Mitchell D.
Ehrlich Daniel J.
Hogan Michael E.
Hollis Mark
Chin Christopher L.
Housel James C.
Houston Advanced Research Center
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