Multi-cyclic compounds and method of use

Details Multi-cyclic compounds and method of use Multi-cyclic compounds and method of use

2011-01-11

2011-01-11

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S288000, C514S341000, C514S345000, C514S269000, C514S275000, C514S241000, C544S242000, C544S180000

Reexamination Certificate

active

07868177

ABSTRACT:
The present invention relates to chemical compounds having a general formula Iwherein A, B, C1, C2, D, L1, L2and R3-4are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

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