Monothioglycerol as thiol-protector in lyophilized materials

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...

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25217412, C12N 996

Patent

active

044422121

ABSTRACT:
A lyophilized product containing monothioglycerol, sulfhydryl-requiring enzyme and a specially prepared serum matrix, useful in the clinical laboratory when reconstituted, is provided.

REFERENCES:
patent: 3066211 (1962-11-01), Milford et al.
patent: 4118279 (1978-10-01), Determann
patent: 4247643 (1981-01-01), Kramer et al.
G. Szasz, "Proceedings of the Second International Symposium on Clinical Enzymology", 1975, pp. III-1 to 36.
L. G. Morin, Clinical Chemistry, 23 (9) 1569, (1977).
G. Szasz et al., Clinical Chemistry, vol. 24, No. 9, 1557, (1978).
Evans Chemetics, Inc.'s brochure on "Thioglycerol".
A. P. MacKenzie, "The Physico-Chemical Basis for the Freeze-Drying Process", International Sumposium on Freeze-Drying of Biological Products, vol. 36, pp. 51-67, (1977).

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