Monoclonal antibody to endothelin-3 or precursor thereof and use

Details Monoclonal antibody to endothelin-3 or precursor thereof and use Monoclonal antibody to endothelin-3 or precursor thereof and use

1990-07-18

1993-07-27

Lacey, David L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 72, 43524027, 5303881, 53038824, 436518, G01N 3353, G01N 33543, C12N 512, C07K 1528

Patent

active

052309991

ABSTRACT:
Disclosed are monoclonal antibodies having an affinity for endothelin-3 or a precursor thereof; a hybridoma cell which produces the monoclonal antibody; and an immunoassay of endothelin-3 and big endothelin-3, a precursor of endothelin-3, by a sandwich method or a competitive method. The monoclonal antibodies can be used as strong antagonists for endothelin-3 in various endothelin-3-related diseases, and the immunoassays make it possible to determine endothelin-3 and big endothelin-3 with high sensitivity.

REFERENCES:
Matsumoto, H. et al, Biochem Biophys Res Com, 164 (1):74-80, Oct. 16, 1989.
Saito, et al., Biochem Biophys Res Com, 161(1):320-326, May 30, 1989.
Yanagisawa, M. et al., Proc. Natl. Acad. Sci, 85: 6964-6967, Sep. 1988.
Inoue, A. et al., Proc. Natl. Acad. Sci, 86: 2863-2867, Apr. 1989.
Nakajima, K. et al., J. of Card. Pharm., 13 (Suppl. 5): 58-512, 1989.
N. Suzuki, et al., Journal of Immunological Methods, 118, 245-250 (1989).
U.S. Ser. No. 07/317,680, date Feb. 1, 1989, Suzuki, et al.
U.S. Ser. No. 07/583,879, date Aug. 30, 1990, Onda et al.

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