Monoclonal antibody against ricin A chain

Details Monoclonal antibody against ricin A chain Monoclonal antibody against ricin A chain

1994-12-27

1997-05-06

Adams, Donald E.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241301, 5303871, 5303881, 5303885, 604171, A61K 39395, C07K 1616, A61M 520

Patent

active

056268440

ABSTRACT:
Monoclonal antibodies against the A chain of ricin have been found to be ective in protecting mammals from morbidity arising from exposure to ricin toxin. The neutralizing action of the antibodies does not appear to be mediated by complement or by immunoprecipitation. The antibodies of the invention are characterized as of isotype IgG1 having the binding characteristics which include: a) binding specifically to the neutralizing epitope of the ricin A chain and b) providing in vitro protection of at least 95% of EL-4 cells from 100 .eta.g/mL ricin challenge when said antibody is present in the tissue culture at a level of at least 1000 .eta.g/mL.

REFERENCES:
Houston [J. Toxicol Clin. Toxicol. 19(4):385-389 (1982)].
Waldmann [Science 252:1657-1662 (1991)].
Harris et al. [TIBTECH 11:42-44 (1993)].
Youle et al. [JBC 262(10):4676-4682 (1987)].
Foxwell et al. [Toxicology 34(1):79-88 (1985)].

Affiliated with

Also associated with

Rating

Monoclonal antibody against ricin A chain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibody against ricin A chain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody against ricin A chain will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2130473