Monoclonal antibodies which specifically bind to human immune in

Details Monoclonal antibodies which specifically bind to human immune in Monoclonal antibodies which specifically bind to human immune in

1983-04-15

1986-07-08

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 68, 4351722, 435240, 436518, 436536, 436548, 935104, 935108, 935110, 350351, 350413, G01N 5300, C12N 1500, C12N 500

Patent

active

045993068

ABSTRACT:
Disclosed are monoclonal antibody substances specifically immunologically reactive with native and recombinant human immune interferon ("IFN-.gamma.") and with polypeptides having amino acid sequences substantially duplicative of sequences extant in IFN-.gamma.. In a presently preferred embodiment, antibody substances are produced by new mouse-mouse hybridoma tumor cell line A.T.C.C. HB 8291 and are immunoreactive with native IFN-.gamma., with recombinant IFN-.gamma. and polypeptide analogs thereof, and with a nonadecapeptide whose amino acid sequence duplicates that of the final nineteen amino acid residues of the carboxyl terminal of IFN-.gamma.. These preferred antibody substances, while displaying high affinity for IFN-.gamma., do not neutralize antiviral biological activity of the interferon. They are usefully employed in the detection, quantification and affinity purification of IFN-.gamma. and IFN-.gamma. analogs as well as in investigations relating to the mode of biological action of IFN-.gamma..

REFERENCES:
patent: 4252791 (1981-02-01), Grossberg et al.
patent: 4285929 (1981-08-01), Sugimoto et al.
patent: 4289690 (1981-09-01), Pestka et al.
patent: 4296025 (1981-10-01), Sugimoto
patent: 4311639 (1982-01-01), Ganfield
patent: 4341761 (1982-07-01), Ganfield et al.
patent: 4362155 (1982-12-01), Skurkovich et al.
patent: 4376821 (1983-03-01), Braude
patent: 4376822 (1983-03-01), Braude
patent: 4382027 (1983-05-01), Braude
patent: 4420398 (1983-12-01), Castino
patent: 4423147 (1983-12-01), Secher et al.
Staehelin, T. et al., J. Biological Chemistry, vol. 256, pp. 9750-9754 (1981).
Maeda, S. et al., Proc. Natl. Acad. Sci. USA, vol. 77 (12), pp. 7010-7013 (12-1980).
Valibracht, A. et al., Nature, vol. 289, pp. 496-497 (2-1981).
Stefanos, S. et al., J. General Virology, vol. 50 (1), pp. 225-229 (1980).
Oleszak, E. et al., Hybridoma, vol. 2(4), pp. 439-449 (12-1983): Oral Disclosure, Nov. 1, 1982, see p. 448.
Meurs, E. et al., Infection and Immunity, vol. 37 (3), pp. 919-926 (9-1982) mc.alpha.hu.alpha.IF.
Secher, D. S., Nature, vol. 290, pp. 501-503, (4-1981).
Langford, M. P. et al., J. Immunology, vol. 126 (4), pp. 1620-1623 (4-1981).
Rubin, B. Y. et al., Journal of Immunology, vol. 130, pp. 1019-1020 (Mar. 1983).
Osborn, J. C., IRCS Med. Sci: Libr. Compend., vol. 8 (4), p. 212 (1980).
Alton, K. et al., Biol. Interferon Sep., Proc. Int., De Maeyer et al., ed., pp. 119-128 (1983), Elsevier, Netherlands.
Spitalny, G. J., J. Exp. Med., vol. 159(5), pp. 1560-1565 (1984).
Altrock, B. et al., Biol. Interferon, Syst. Proc. Int., De Maeyer et al., ed., pp. 135-138 (1983), Elsevier, Netherlands.
De Maeyer, E. et al., ed., The Biology of the Interferon System, Elsevier, Amsterdam (1983).
Hochkeppel, H. K. et al., Nature, vol. 296, pp. 258-259 (1982).
Yip, Y. K. et al., Proc. Natl. Acad. Sci. USA, vol. 79, pp. 1820-1825 (1982).
Yip, Y. P. et al., Science, vol. 245, pp. 411-412, (1982).
Le, J. et al., J. Immunological Methods, vol. 69 (1), pp. 61-70 (1984).
Le, J. et al. J. Immunology, vol. 132(3), pp. 1300-1304 (1984).
Novick, D. et al., Embo. Journal, vol. 2(9), pp. 1527-1530 (1983).
Johnson, H. M. et al., J. Immunology, vol. 129(6), pp. 2357-2359 (1982).
Baron et al., Cell, 28: 395-404 (1982).
Burnett, Anal. Biochem., 112: 195-203 (1981).
Chisholm, High Technology, 3(1): 57-63 (1983).
Dreesman et al., Nature, 295: 158-160 (1982).
Edge et al., Nature, 292: 756-782 (1981).
Goding, J. Imm. Methods, 39: 285-308 (1980).
Gray et al., Nature, 295: 503-508 (1982).
Green et al., Cell, 28: 477-487 (1982).
Hopp et al., PNAS (USA), 78: 3824-3828 (1981).
Hunter et al., Nature, 194: 495-496 (1962).
Imai et al., J. Immunology, 128: 2824-2825 (1982).
Lerner et al., Cell, 23: 309-310 (1981).
Lerner et al., PNAS (USA), 78: 3403-3407 (1981).
Lerner, Scientific American, 248(2): 66-74 (1983).
Merrifield, J. Amer. Chem. Soc., 85: 2149-2154 (1963).
Nigg et al., PNAS (USA), 79: 5322-5326 (1982).
Oi et al., pp. 351-372, in Selected Methods in Cellular Immunology, (Mishell et al., eds.), W. H. Freeman Publishing, San Francisco (1979).
Ross et al., Nature, 294: 654-656 (1981).
Shulman et al., Nature, 276: 269-279 (1978).
Secher et al., Nature, 285: 446-450 (1980).
Staehelin et al., PNAS, 78: 1848-1852 (1981).
Todd et al., T.I.B.S., 7: 212-216 (1982).
Walter et al., PNAS (USA), 77: 5197-5200 (1980).
Walter et al., PNAS (USA), 78: 4882-4886 (1981).
Wong et al., PNAS (USA), 78: 7412-7416 (1981).

Affiliated with

Also associated with

Rating

Monoclonal antibodies which specifically bind to human immune in does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibodies which specifically bind to human immune in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies which specifically bind to human immune in will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1451089