Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-06-09
1990-10-16
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530380, 530382, 530383, 530388, 530413, 530415, 530417, 43524027, 435 5, 435 7, 424 858, A61K 39395, C07K 1528
Patent
active
049636570
ABSTRACT:
Novel cell lines produce monoclonal antibody to the light chain region of human factor XII. Three such cell lines, ATCC #HB-9703 through ATCC #HB-9704, are formed by fusing SP2/0-Ag14 myeloma cells with spleen cells from BALB/c AnSkh mice immunized with human factor XIIf. Biochemical and therapeutic uses of the monoclonal antibodies are provided.
REFERENCES:
Akiyama et al., J. Clin. Invest., 78(6), 1631-37, (12/86).
Clarke et al., J. Biol. Chem., 264(19), 11497-502, (7/89).
Campbell, Monoclonal Antibody Technology, chapters 3,4 and 6-10 as supplied, (Elsevier, N.Y.,) 1985.
Saito et al., "Production and Characterization of a Murine Monoclonal Antibody Against a Heavy Chain of Hageman Factor (Factor XII)", Blood 65:1263-1268 (1985).
Small et al., "A Monoclonal Antibody That Inhibits Activation of Human Hageman Factor (Factor XII)" Blood, 65:202-210 (1985).
Laemmle et al., "Enhanced Specificity of Immunoblotting Using Radiolabeled Antigen Overlay: Studies of Bood Coagulation Factor XII and Prekallikrein in Plasma" Anal. Biochem. 156:118-125 (1986).
Laemmle etal., "Quantitative Immunoblotting Assay of Blood Coagulation Factor XII" Thromb. Res. 41:747-759 (1986).
Pixley et al., "A Monoclonal Antibody Recognizing an Icosapeptide Sequence in the Heavy Chain of Human Factor XII Inhibits Surface-Catalyzed Activation" J. Biol. Chem. 262:10140-10145 (1987).
Sugihara et al., "Application of a Monoclonal Antibody Against Factor XII (Hageman Factor); Enzyme-Linked Immunosorbent Assay (ELISA) for Factor XII Antigen", Acta Haematologica Japonica 50:691-5 (May 1987).
Kushan Jeff
Moezie F. T.
Temple University Of The Commonwealth System Of Higher Education
LandOfFree
Monoclonal antibodies to the light chain region of human factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies to the light chain region of human factor , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies to the light chain region of human factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-850602