Monoclonal antibodies to human bladder and ureter cancers and me

Details Monoclonal antibodies to human bladder and ureter cancers and me Monoclonal antibodies to human bladder and ureter cancers and me

1983-12-30

1987-02-17

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

436548, 935104, 4351722, 435948, 530387, C12N 500, C12N 1500, C12R 191, A61K 39395

Patent

active

046439714

ABSTRACT:
A panel of monoclonal antibodies, produced from human bladder tumors as immunogen, is used to diagnose the presence of transitional cell carcinoma in patients. The panel is also used to identify and differentiate low grade non-invasive papillomas from invasive life-threatening transitional cell carcinomas, thereby enabling decisions as to the extent of bladder surgery. These mAbs can also be used as a panel for tissue typing of normal and abnormal cell specimens.

REFERENCES:
patent: 4363799 (1982-12-01), Kung et al.
Bubbers et al., "Monoclonal Antibodies to Human Tumor Associated Antigens on Transitional Cell Carcinoma", Federation Proceedings 41(3), p. 726 (1982).
Starling et al., "Monoclonal Antibodies to Human Prostate and Bladder Tumor Associated Antigens", Cancer Research 42, pp. 3084-3089 (1982).
Metzgar et al., "Antigens of Human Pancreatic Adenocarcinoma Cells Defined by Murine Monoclonal Antibodies", Cancer Research 42, pp. 601-608 (1982).

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