Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1985-01-07
1987-12-29
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4351722, 435 68, 436548, 935 89, 935 95, 935102, 935103, 935104, 935105, 935106, 935108, 935110, 424 85, A61K 39395, G01N 33597
Patent
active
047161175
ABSTRACT:
Hybridomas producing monoclonal antibodies specific for polypeptide fragments derived from human Factor VIIIC are provided. Class I hybridomas produce monoclonal antibodies reactive with a 80/77 kd doublet fragment or with both the 80/77 kd doublet and a 240 kd polypeptide. Class III hybridomas produce monoclonal antibodies reactive with the 240 kd polypeptide as well as a 92.5 kd fragment and its precursors. Class III antibodies show additional reactivity with a 40 kd thrombin digestion product. The monoclonal antibodies are useful for the separation of Factor VIIIC and its constituent polypeptides, as well as for the immunoassay of Factor VIIIC in biological samples.
REFERENCES:
patent: 4361509 (1982-11-01), Zimmerman et al.
patent: 4649132 (1987-03-01), Zimmerman et al.
patent: 4657894 (1987-04-01), Zimmerman et al.
Fulcher & Zimmerman, Proc. Natl. Acad. Sci USA (1982) 79: 1648-1652.
Tuddenham et al., (1979) J. of Lab. Clinical Medicine, 93: 40-53.
Austen, (1979), British J. Hematology, 43: 669-674.
Weinstein et al., (1981), Proc. Natl. Acad. Sci USA, 78: 5137-5141.
Kuo et al., Abstracts for IX International Congress of Thrombosis Hemostasis, (Stockholm, Jul. 1983).
Hybritech Data Sheet (Catalogue #0432).
Fulcher et al., (1983) Blood 61: 807.
Fass et al., (1982) Blood 59: 594.
Kurachi et al., (1982), Proc. Natl. Acad. Sci. USA 79: 6461-6464.
Maniatis et al., Molecular Cloning: A Laboratory Manual, pp. 224-228, (1982).
Bloom, (1983), Nature 303: 474-475.
Muller et al., (1981), Blood 58: 1000-1006.
Maddox, (1983), Nature 306: 528.
Rotblat et al., (1984), Biological Abstracts 77: 4443, (Abstract No. 40713).
Rotblat et al., (1983), J. Lab. Clin. & Med. 101: 736-746.
Wood et al., (1984), Nature 312: 330-337.
Toole et al., (1984), Nature 312: 342-347.
Favaloro Jennifer
Kuo George
Masiarz Frank R.
Rasmussen Mirella E.
Truett Martha
Chiron Corporation
Nordisk Gentofte
Nucker Christine M.
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