Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-02
1998-07-14
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303892, 530351, 5303871, 530806, C07K 1624, C12P 2108
Patent
active
057805970
ABSTRACT:
The present invention relates to antibodies which bind to a novel cytotoxic lymphocyte maturation factor. When bound to the cytotoxic lymphocyte maturation factor, the antibodies can neutralize bioactivity of the factor.
REFERENCES:
patent: 5457038 (1995-10-01), Trinchieri et al.
patent: 5569454 (1996-10-01), Trinchieri et al.
patent: 5648072 (1997-07-01), Trinchieri et al.
patent: 5648467 (1997-07-01), Trinchieri et al.
Kobayashi et al., "Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple bioolgic effects on human lymphocytes", J. Exp. Med. 170:827-845 (1989).
Gately et al. "Synergy between recombinant interleukin 2 (rIL 2) and IL 2-depleted lymphokine-containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro", J. of Immunol. 136:1274-1282 (1986).
Gately et al., "Interleukin-12:a novel heterodimeric cytokine with potential antitumor applications", Neuroimmunological Research 4:20-32 (1991).
Chizzonite et al., "Cytotoxic lymphocyte maturation factor (CLMF): receptor on PHA-activated peripheral blood lymphoblasts (PHA-PBL) mediates binding and biological activity", FASEB J. 5:5568 (1991).
Desai et al., "Regulation of human lymphocyte proliferation by cytotoxic lymphocyte maturation factor (CLMF)", FASEB J. 5:2069 (1991).
Gately et al., "Synergy between recombinant interleukin-2 (rIL-2) and IL-2-depleted lymphokine supernatants (LKS) in facilitating human cytolytic lymphocyte (CTL) responses in vitro", Fed. Proc. 44:947 (1985).
Wong et al., "Characterization of a human CTL maturation factor", Abs. 6th Int'l. Congress of Immunol. 311 (1986).
Merberg et al., "Sequence similarity between NKSF and the IL-6/G-CSF family", Immunology Today 13:77-78 (1992).
Podlaski et al., "Molecular characterization of a novel cytokine:cytotoxic lymphocyte maturation factor", Abs. J. Cellular Biochem. Suppl. 15F:78 (1991).
Truitt et al., "Initial characterization of the receptor for cytotoxic lymphocyte maturation factor (CLMF) on PHA-activated human peripheral blood lymphoblasts (PHA-PBL)", Abs. J. Cellular Biochem. Suppl. 15F:120 (1991).
Gately et al., "In vitro studies on the cell-mediated immune response to human brain tumors. 1. Requirement for third-party stimulator lymphocytes in the induction of cell-mediated cytotoxic responses to allogeneic cultured gliomas", JNCI 69:1245-1254 (1982).
Gubler et al., "Cloning and expression of cytotoxic lymphocyte maturation factor (CLMF), a heterodimeric lymphokine that potentiates NK, LAK and T-cell responses", Abs. J. Cellular Biochem. Suppl. 15F:70 (1991).
Gubler et al., "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor", Proc. Natl. Acad. Sci. 88:4143-4147 (1991).
Gately et al., "Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factro)", J. Immunol. 147:874-882 (1991).
Chizzonite et al. "IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts", J. Immunol. 147:1548-1556 (1991).
Chan et al., "Induction of interferon .gamma. production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers", J. Exp. Med. 173:869-879 (1991).
Stern et al., "Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells", Proc. Natl. Acad. Sci. USA 87:6808-6812 (1990).
Lieberman et al., "Natural killer cell stimulatory factor (NKSF) augments natural killer cell and antibody-dependent tumorcidal response against colon carcinoma cell lines", J. of Surgical Res. 50:410-415 (1991).
Gearing and Cosman, "Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor", Apr. 3, 1996 Cell 66:9-10 (1991).
Gately et al., "Isolation and characterization of a novel lymphokine which synegizes with IL-2 in the generation of activated NK/LAK cells", Lymphokine research 9:566 (1990).
Chan et al., "Mechanisms of IFN-.gamma. induction by natural killer cell stimulatory factor (NKSF/IL-2)", J. of Immunol. 148:92-98 (1992).
Podlaski et al., "Molecular characterization of interleukin 12", Archives of Biochem. & Biophys. 294:230-237 (1992).
Chehimi et al., "Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients", J. Exp. Med. 175:789-796 (1992).
Robertson et al., "Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF", J. Exp. Med. 175:779-788 (1992).
Thiele et al. "Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester", J. of Immunol. 131:2282-2290 (1983).
Sinosich et al., "Affinity immunoelectrophoresis and chromatography for isolation and characterization of a placental granulocyte elastase inhibitor", Protein Purification, Richard Burgess, ed., Alan R. Liss, Inc. pp. 225-238 (1987).
Richard et al., "Cytokines involved in the augmentation of murine natural killer cell activity by pyrimidinones in vivo", J. Biol. Resp. Modifiers 6:647-663 (1987).
Lanier et al., "Interleukin 2 activation of natural killer cells rapdily induces the expression and phosphorylation of the Leu-23 activation antigen", J. Exp. Med. 167:1572-1585 (1988).
Katayama et al., "Comparision of amino acid sequence of bovine coagulation factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins", Proc. Natl. Acad. Sci. USA 76:4990-4994 (1979).
Casagli et al., "Purification of recombinant human interleukin 1.beta. produced from yeast", Protein Purification, Alan R. Liss, Inc. pp. 421-427 (1987).
Wasserman et al., "Purification and characterization of recombinant human malaria vaccine candidates from E. coli", Protein Purification, Richard Burgess, ed., Alan R. Liss, Inc. pp. 337-354 (1987).
Wong et al., "Characterization of a factor(s)which synergizes with recombinant interleukin 2 in promoting allogeneic human cytollytic T-lymphocyte responses in vitro", Cellular Immunol. 111:39-54 (1988).
Truitt et al., "Initial characterization of the receptor for cytotoxic lymphocyte maturation factor (CLMF) on PHA-activated human peripheral blood lymphoblasts (PHA-PBL)", Abs. J. Cellular Biochem. Suppl. 15F:120 (1991).
Wolf et al., "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells", J. Immunol. 146:3074-3081 (1991).
Ichimura et al., "characterization of mouse natural killer cell activating factor (NKAF) induced by OK-432: evidence for interferon-and interleukin 2-independent NK cell activation", Br. J. Cancer 50:97-108 (1984).
Devos et al., "Molecular cloning of human interleukin 2 cDNA and its expression in E. coli", Nucleic Acids Res. 11:4307-4323 (1983).
Talmadge, "Immunoregulation and immunostimulation of murine lymphocytes by recombinant human interleukin-2", J. Biol. Res. Modifiers 4:18-34 (1985).
Petranyi et al., "Natural killer cells in man: genetic and other factors regulating their activity", Progress in Immunology V 5:1169, 1174-1175, 1178-1180 (1983).
Heberman and Ortaldo, "Natural killer cells: their role in defenses against disease", Science 214:24-30 (1981).
Aggarwal, Protein Purification, Richard Burgess, ed., Alan R. Liss, Inc., p. 22 (1987).
Wong and Clark, "Multiple actions of interleukin 6 within a cytokine network", Immunology Today 9:137-139 (1988).
Smith, K. et al. J. of Immunol. 131, pp. 1808-1815 (1983).
Chizzonite Richard Anthony
Gately Maurice Kent
Gubler Ulrich Andreas
Hulmes Jeffrey David
Pan Yu-Ching Eugene
Buchholz Briana C.
Cunningham Thomas M.
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
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