Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1993-05-25
1998-08-18
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241331, 4241351, 4241431, 4241411, 4241781, 4241541, 4241561, 5303873, 5303881, 53038822, 5303913, C07K 1628, A61K 39395, A61K 3944, G01N 3353
Patent
active
057955727
ABSTRACT:
An anti-CD2 monoclonal antibody according to the present invention can be: (1) a chimeric monoclonal antibody CD2 SFv-Ig produced by expression of the construct cloned in recombinant Escherichia coli culture ATCC No. 69277; (2) a monoclonal antibody having complementarity-determining regions identical with those of CD2 SFv-Ig; or (3) a monoclonal antibody competing with CD2 SFv-Ig for binding to CD2 antigen at least about 80% as effectively on a molar basis as CD2 SFv-Ig. Anti-CD2 monoclonal antibodies according to the present invention, as well as other antibodies that can modulate the interactions between T lymphocytes and monocytes, can be used to inhibit the production of HIV-1 by HIV-1-infected T cells in HIV-1-infected patients. In another use, T cells treated in vitro can be reinfused into AIDS patients to increase the proportion of functional, non-HIV-1-producing T cells in the patient.
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C.J.M. van Noesel et
Diegel Michael L.
Gilliland Lisa K.
Ledbetter Jeffrey A.
Linsley Peter S.
Moran Patricia A.
Bristol--Myers Squibb Company
Feisee Lila
Lucas John
LandOfFree
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