Radiation imagery chemistry: process – composition – or product th – Imaging affecting physical property of radiation sensitive...
Patent
1995-06-07
1996-12-24
Chapman, Mark
Radiation imagery chemistry: process, composition, or product th
Imaging affecting physical property of radiation sensitive...
430296, 430942, 356361, G03C 500
Patent
active
055872735
ABSTRACT:
A molecularly imprinted substrate and sensors employing the imprinted substrate for detecting the presence or absence of analytes are described. One embodiment of the invention comprises first forming a solution comprising a solvent and (a) a polymeric material capable of undergoing an addition reaction with a nitrene, (b) a crosslinking agent (c) a functionalizing monomer and (d) an imprinting molecule. A silicon wafer is spincoated with the solution. The solvent is evaporated to form a film on the silicon wafer. The film is exposed to an energy source to crosslink the substrate, and the imprinting molecule is then extracted from the film. The invention can be used to detect an analyte by forming films which are then exposed to a reaction energy to form a crosslinked substrate. The imprinting molecules are extracted from the crosslinked substrate. The film is exposed to one or more of the imprinting molecules for a period of time sufficient to couple the imprinting molecules to the film. The presence of the molecules is then detected. The invention also provides a molecularly imprinted polymeric material and sensors employing the molecularly imprinted polymeric material.
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Keana John F. W.
Sevrain Christophe J. P.
Wybourne Martin N.
Yan Mingdi
Advanced Microbotics Corporation
Chapman Mark
State of Oregon Acting By and Through the State Board of Higher
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