Molecular detection using an optical waveguide fixed to a...

Details Molecular detection using an optical waveguide fixed to a... Molecular detection using an optical waveguide fixed to a...

2007-01-02

2007-01-02

Pak, Sung (Department: 2874)

Optical waveguides

Optical waveguide sensor

Including physical deformation or movement of waveguide

C385S012000, C073S064430, C073S800000, C356S073100

Reexamination Certificate

active

11240151

ABSTRACT:
The invention relates to devices and methods for detecting a ligand in a liquid, based on deflection of one or more microscopic cantilevers. Each cantilever has an optical waveguide fixed thereto or integral therewith. Deflection of the cantilever is detected by assessing coupling of light between the optical waveguide on the cantilever and an optical waveguide fixed distally thereto.

REFERENCES:
patent: 5671303 (1997-09-01), Shieh et al.
patent: 5807758 (1998-09-01), Lee et al.
patent: 5982009 (1999-11-01), Hong et al.
patent: 6269685 (2001-08-01), Oden
patent: 6346376 (2002-02-01), Sigrist et al.
patent: 6436647 (2002-08-01), Quate et al.
patent: 6575020 (2003-06-01), de Charmoy Grey et al.
patent: 2002/0074513 (2002-06-01), Abel et al.
Alvarez et al., 2003, “Development of a Nanomechanical Biosensor for Oligonucleotide Hybridization Detection,” web page accessed Apr. 24, 2003, at www.imm.cnm.csic.es/biosensores/home.
Baller et al., 2000, Ultramicroscopy 82:(1-4) 1-9 (Abstract only).
“Development and Fabrication of a Nanobiochip based on Microcantilevers,” web page, accessed Apr. 24, 2003 at www.imm.cnm.csic.es/biosensores/cantilever- development.htm.
Fritz et al., 2000, Science, 288:316-318.
Gimzewski, 2003, “Translating Biochemical Recognition into Nanomechanical Action,” web page, accessed Apr. 24, 2003 at www.chem.ucla.edu/dept/Faculty/gimzewski/id11.htm.
Grogan et al., 2002 Biosens. Bioelectron. 17(3):201-207 (Abstract only).
Hofmann et al., 2002 Anal. Chem. 74 (20): 5243-5250 (Abstract only).
Institute of Microsystem Technologies, web page, “PECVD Process” accessed Apr. 15, 2003 at www.uni-siegen.de/ihe/forschung/pecvd-e.htm.
Lavrik et al., 2003, Appl. Phys. Lett. Apr. 21, 2003 (Abstract and Figure only).
LioniX BV, 2003, web page, “PECVD Silicon Technology (SiOxNy),” accessed Apr. 15, 2003 at www.lionphotonix.nl/technology/processes—pecvdsioxny.html.
LioniX-Sion Technology, web page, “Sion Technology”, accessed Apr. 15, 2003 at www.lionixbv.nl/technology/io—sion.html.
McKendry et al., 2002, Proc. Natl. Acad. Sci. USA 99:(15):9783-9788.
“Methods of Controlled Immobilization at DNA Probes,” web page, accessed Apr. 24, 2003 at www.imm.cnm.csic.es/biosensores/cantilever-immobilization.htm.
MicroVacuum, Ltd., 2003, catalog entry OW 2400c, accessed Apr. 15, 2003 at www.microvacuum.com/products/biosensor.
MicroVacuum, Ltd., 2003, catalog entry OW 3200, accessed Apr. 14, 2003, at www.microvacuum.com/products/biosensor/OW3200.asp.
Moulin et al., 1999, Langmuir 15:8776-8779.
Moulin et al., 2000 Ultramicroscopy 82:(1-4):23-31 (Abstract only).
Raiteri et al, 2000, Electrochim. Acta 46:157-163.
Stimpson et al., 1995, Proc. Natl. Acad. Sci. USA 92:6379-6383.
“Synthesis of Silicon Oxynitride Films on Porous Substrates” web page, accessed Apr. 15, 2003 at www.icmm.csic.es/fis/english/oxinitruro—de—silicio.html.
Tamayo et al., 2001, Ultramicroscopy 86:167-173.
Wu et al., 2001, Nat. Biotechnol. 19:856-860.
Wu et al., 2001, Proc. Natl. Acad. Sci. USA 98(4):1560-1564.

Affiliated with

Also associated with

Rating

Molecular detection using an optical waveguide fixed to a... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Molecular detection using an optical waveguide fixed to a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecular detection using an optical waveguide fixed to a... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3725148