Molecular clones of HIV-1 viral strains MN-ST1 and BA-L and uses

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435239, 435 6, 435 691, 435 693, 536 2372, 530324, C12N 700

Patent

active

054200300

ABSTRACT:
The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.

REFERENCES:
Science, vol. 241, issued 22 Jul. 1988, W. C. Koff et al, Development and Testing of AIDS Vaccines, pp. 426-432.
Nature, vol. 312, issued 20/27 Dec. 1984, P. A. Luciw et al, Molecular cloning of AIDS-associated retrovirus, pp. 760-763.
Science, vol. 226, issued 07 Dec. 1984, G. M. Shaw et al, Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the AIDS, pp. 1165-1171.
Nature, vol. 312, issued 20/27 Dec. 1984, M. Alizon et al, "Molecular cloning of lymphadenopathy-associated virus," pp. 757-760.
Journal of Medical Virology, vol. 19, issued 1986, H. R. bsamen-Waigmann et al, "Isolation of Variants of Luymphocytopathic Retroviruses From the Peripheral Blood and Cerebrospinal Fluid of Patients With ARC of AIDS," pp. 335-344.
Nature, vol. 313, issued 24 Jan. 1985, L. Ratner et al, "Complete nucleotide sequence of the AIDS virus, HTLV-III," pp. 277-284.
Cell, vol. 40, issued Jan. 1985, S. Wain-Hobson et al, "Nucleotide Sequence of the AIDS virus, LAV," pp. 9-17.
Science, vol. 227, issued 01 Feb. 1985, R. Sanchez-Pescador et al, "Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)," pp. 484-492.
Nature, vol. 313, issued 07 Feb. 1985, M. A. Muesing et al, "Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus," pp. 450-458.
Nature, vol. 320, issued 10 Apr. 1986, S.-L. Hu et al, "Expression of AIDS virus envelope gene in recombinant vaccinia viruses," pp. 537-540.
Nature, vol. 320, issued 10 Apr. 1986, S. Chatrabarti et al, "Expression of the HTLV-III envelope gene by a recombinant vaccinia virus," pp. 535-537.
Bio/Technology, vol. 3 issued Oct. 1985, T. W. Chang et al, "Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) with an Immunoassay Employing a Recombinant Escherichia coli-Derived Viral Antigenic Peptide," pp. 905-909.
Proc. Natl. Acad. Sci. USA, vol. 84, issued Oct. 1987, J. R. Rusche et al, "Humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cell," pp. 6924-6928.
J. Virology, vol. 63, No. 3, issued Mar. 1989, M. Hadzopoulou-Cladaras et al, "The rev (trs/art) Protein of Human Immunodeficiency Virus Type 1 Affects Viral mRNA and Protein Expression via a cis-Acting Sequence in the env Region," pp. 1265-1274.
J. Virology, vol. 64, No. 9, issued Sep. 1990, P. J. Dillion et al, "Function of the Human Immunodeficiency Virus Types 1 and 2 Rev Proteins Is Dependent on Their Ability To interact with a Structured Region Present in env Gene mRNA," pp. 4428-4437.
Cell, vol. 45, issued 06 Jun. 1986, B. R. Starcich et al, "Identification and Characterization of Conserved and Variable Regions in the Envelope Gene of HTLV-III/LAV, the Retrovirus of AIDS," pp. 637-648.
J. Virology, vol. 61, No. 2, issued Feb. 1986, S. Modrow et al, "Computer-Assisted Analysis of Envelope Protein Sequences of Seven Human Immunodeficiency Virus Isolates: Pediction of Antigenic Epitopes in Conserved and Viriable Regions," pp. 570-578.
Analytical Biochemistry, vol. 151, issued 1985, D. Pauletti et al, "Application of a Modified Computer Algorithm in Determining Potential Antigenic Determinants Associated with the AIDS Virus Glycoprotein," pp. 540-546.
Virology, vol. 164, issued 1988, C. Gurgo et al, "Envelope Sequences of Two New United States HIV-1 Isolates," pp. 531-536.
J. Virology, vol. 64, No. 5, issued May 1990, A. Aldovini et al, "Mutations of RNA and Protein Sequences Involved in Human Immunodeficiency Virus Type 1 Packaging Result in Production of Noninfectious Virus," pp. 1920-1926.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Molecular clones of HIV-1 viral strains MN-ST1 and BA-L and uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Molecular clones of HIV-1 viral strains MN-ST1 and BA-L and uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecular clones of HIV-1 viral strains MN-ST1 and BA-L and uses will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-360881

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.