Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-03-04
2008-03-04
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S372000, C514S374000
Reexamination Certificate
active
10839221
ABSTRACT:
The present invention relates to the use of compounds of the general Formula (XIII):whereinA7is C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13;A8is C(R14)2, O, S, or NR12;A9is C═O, C═S, SO2, CH—OR13, C═NR12,or CH2—CHOR13;m is 0, or 1q is 0, or 1r is 0, or 1R12is H, CH3, CH2—CH3, C6H5, OCH3, OCH2—CH3, OH, or SH;R13is H, CH3, or CH2—CH3;R14is H, alkyl, alkoxy, OH, or SH.
REFERENCES:
patent: 3265506 (1966-08-01), Weissberger et al.
patent: 4069252 (1978-01-01), Findeisen
patent: 4146454 (1979-03-01), Haber
patent: 4436479 (1984-03-01), Belloli
patent: 5155011 (1992-10-01), Zertani
patent: 5190928 (1993-03-01), Schurter
patent: 5395730 (1995-03-01), Podszun
patent: 5523311 (1996-06-01), Schurter
patent: 5585473 (1996-12-01), Bendiak
patent: 5612359 (1997-03-01), Murugesan
patent: 5846990 (1998-12-01), Murugesan
patent: 5990109 (1999-11-01), Chen
patent: 6159980 (2000-12-01), Arvanitis
patent: 6300352 (2001-10-01), Cheshire
patent: 6395282 (2002-05-01), Kende et al.
patent: 6399773 (2002-06-01), Liu
patent: 6476042 (2002-11-01), Harrison
patent: 6555540 (2003-04-01), Mylari
patent: 6815528 (2004-11-01), Wang
patent: 6858627 (2005-02-01), Bekkali
patent: 6894111 (2005-05-01), Wang
patent: 2004/0019117 (2004-01-01), Protopopova
patent: 2004/0033986 (2004-02-01), Protopopova
patent: 2006/0073667 (2006-04-01), Li
patent: 101 18 310 (2002-10-01), None
patent: 0 525 686 (1993-02-01), None
patent: 0 540 472 (1993-05-01), None
patent: 0 638 545 (1995-02-01), None
patent: 0 982 292 (2000-03-01), None
patent: 1 439 334 (1966-04-01), None
patent: 2 331 299 (1999-05-01), None
patent: 3-232849 (1991-10-01), None
patent: 95/01175 (1995-01-01), None
patent: WO 95/24403 (1995-09-01), None
patent: 96/29392 (1996-09-01), None
patent: 98/57618 (1998-12-01), None
patent: 98/58075 (1998-12-01), None
patent: WO 98/57618 (1998-12-01), None
patent: WO 99/27786 (1999-06-01), None
patent: 99/53915 (1999-10-01), None
patent: 99/55368 (1999-11-01), None
patent: 01/26650 (2001-04-01), None
patent: 01/51456 (2001-07-01), None
patent: WO 01/90090 (2001-11-01), None
patent: 02/088298 (2002-11-01), None
patent: 03/004017 (2003-01-01), None
patent: WO/03/015778 (2003-02-01), None
patent: 03/022828 (2003-03-01), None
patent: 03/026641 (2003-04-01), None
patent: WO 03/039529 (2003-05-01), None
patent: WO 03/039549 (2003-05-01), None
Hentzer, M., et al. Microbiology 2002, 148, 87-102.
Patent Abstracts of Japan, JP 59-210440, Nov. 29, 1984.
C. S. Pak, et al., Synthesis, vol. 12, XP-001154580, pp. 1213-1214, “Aminolysis of 5-Acyl-2,2-Dimethyl-1,3-Dioxane-4,6-Diones (Acyl Meldrum's Acids) as a Versatile Method for the Synthesis of β-Oxo Carboxamides”, Dec. 1992.
K. M. Smith, et al., Chemistry & Biology, vol. 10, No. 1, XP-002254860, pp. 81-89, “Induction and Inhibition ofPseudomonas aeruginosaQuorum Sensing by Synthetic Autoinducer Analogs”, Jan. 2003.
Fuqua, C., et al., “Census and Consensus in Bacterial Ecosystems: The LuxR-LuxI Family of Quorum-Sensing Transcriptional Regulators,” Anne. Rev. Microbiol. 50, pp. 727-751, 1996.
Eberl, L., “N-Acyl Homoserinelactone-mediated Gene Regulation in Gram-negative Bacteria,” System Appl. Microbiol. 22, pp. 493-506, 1999.
De Kievit, T., et al., “Bacterial Quorum Sensing in Pathogenic Relationships,” Infection and Immunity, pp. 4839-4849, Sep. 2000.
Davies, D. G., et al., “The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm,” Science, vol. 280, pp. 295-298, Apr. 10, 1998.
Huber, B., et al., “The cep quorum-sensing system ofBurkholderia cepaciaH111 controls biofilm formation and swarming motility,” Microbiology, 147, pp. 2517-2528, 2001.
Costerton, J. W., et al., “Microbial Biofilms,” Ann. Rev. Microbiol.
Govan, J. R. W., et al., “Microbial Pathogenesis in Cystic Fibrosis: MucoidPseudomonas aeruginosaandBurkholderia cepacia,” Microbiological Reviews, Sep. 1996, pp. 539-574.
Costerton, J. W., et al., “Bacterial Biofilms: A Common Cause of Persistent Infections,” Science, vol. 284, May 21, 1999, pp. 1318-1322.
Lewis, K., “Riddle of Biofilm Resistance,” Antimicrobial Agents and Chemotherapy, Apr. 2000, pp. 999-1007.
Govan, J. R. W., “Burkholderia cepacia:medical, taxonomic and ecological issues,” J. Med. Microbiol. 45, pp. 395-407, 1996.
Chhabra, S. R., et al., “Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone as Immune Modulators,” J. Med. Chem. 2003, 46, pp. 97-104.
Stickler, D. J., et al., “Biofilms on Indwelling Urethral Catheters Produce Quorum-Sensing Molecules in Situ and In Vitro,” Applied and Environmental Microbiology, Sep. 1998, pp. 3486-3490.
Dong, Y. H., et al., “Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase,” Nature, vol. 411, Jun. 14, 2001, pp. 813-817.
Schaefer, A. L., et al., “Quorum Sensing inVibrio fischeri; Probing Autoinducer-LuxR Interactions with Autoinducer Analogs,” Journal of Bacteriology, May 1996, pp. 2897-2901.
Zhu j., et al., “Anagogs of Autoinducer 3-Oxooctanoyl-Homoserine Lactone Strongly Inhibit Activity of the TraR Protein ofAgrobacterium tumefaciens,” Journal Bacteriology, Oct. 1998, pp. 5398-5405.
McClean, K. H., et al., “Quorum sensing andChromobacterium violaceum:exploitation of violacein production and inhibition for the detection of N-acelhomoserine lactones,” Microbiology 143, 1997, 3703-3711.
Swift S., et al., “Quorum Sensing inAeromonas hydrophilaandAeromonas salmonicida:Identification of the LuxRI Homologs AhyRI and AsaRI and Their Cognate N-Acylhomoserine Lactone Signal Molecules,” Journal of Bacteriology, Sep. 1997, pp. 5271-5281.
Pesci, E. C., et al., “Regulation of las and rhl Quorum Sensing inPseudomonas aeruginosa,” Journal of Bacteriology, May 1997, pp. 3127-3132.
Hentzer, M., et al., “Inhibition of quorum sensing inPseudomonas aeruginosabiofilm bacteria by a halogenated furonone compound,” Microbiology, 148, 2002, pp. 87-102.
Smith, K. M., et al., “Library Screening for Synthetic Agonists and Antagonists of aPseudomonas aeruginosaAutoinducer,” Chemistry & Biology, vol. 10, pp. 563-571, Jun. 2003.
Fuqua, W. C., et al., “Quorum Sensing in Bacteria: the LuxR-LuxI Family of Cell Density-Responsive Transcriptional Regulators,” Journal of Bacteriology, Jan. 1994, pp. 269-275.
Oikawa, Y., et al., “Methyl Phenylacetylacetate from Phenylacetyl Chloride and Meldrum's Acid,”Organic Syntheses, CV 7, pp. 359-360.
Oikawa, Y., et al., “Meldrum's Acid in Organic Synthesis 2. A General and Versatile Synthesis of β-Keto Esters,” J. Org. Chem., vol. 43, No. 10, pp. 2087-2088, 1978.
Nakahata, M., et al., “The Preparation of Optically Pure 3-Hydroxyalkanoic Acid. The Enantioface-differentiating Hydrogenation of the C=O Double Bond with Modified Raney Nickel. XXXVII,” Bull. Chem. Soc. Jpn, 55, pp. 2186-2189, 1982.
Matsuo, K., “Structure-Activity Relationships in Tetramic Acids and Their Copper (II) Complexes,” Chem. Pharm. Bull. 28, pp. 2494-2502, 1980.
Monti, L., et al., “Sulla preparazione delle α-ossi-γ-metil-chinoline,” Gass. Chim. Ital. 66, pp. 723-731, 1936.
Dekhane, M., et al., “A Novel Convenient Rout to the Naturally Occurring 3-Oxoacyl-L-Homoserinelactones and Related Bacterial Autoinducers,” Tetrahedron Letters, vol. 37, No. 11, pp. 1883-1884, 1996.
Augelli-Szafran, C., et al., “Inhibitors of Acyl-CoA: Cholesterol Acyltransferase. 5. Identification and Structure-Activity Relationships of Novel β-Ketoamides as Hypocholesterolemic Agents,” J. Med. Chem., 36, pp. 2943-2949, 1993.
Rowley, M., et al., “3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsa
Ammendola Aldo
Aulinger-Fuchs Katharina
Gotschlich Astrid
Kramer Bernd
Lang Martin
Padmanabhan Sreeni
Quonova, LLC
Ramachandran Umamaheswari
Womble Carlyle Sandridge & Rice PLLC
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