Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Chemical stimulation of growth or activity by addition of...
Patent
1995-11-22
1998-08-04
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Chemical stimulation of growth or activity by addition of...
435245, 435923, 435947, C12N 138, C12N 136
Patent
active
057892350
ABSTRACT:
This invention involves a method of altering and regulating the gene expression of cells, by means of contacting the cells with a nuclease capable of degrading extra-cellular DNA and/or RNA. The nuclease will degrade the extra-cellular nucleic acids (NA) into nucleotides or oligonucleotides which are too short to have substantial affinity for the chromosomal DNA.
By means of this method, cultures of cells have been created with desirable properties, including greater phenotypic uniformity and higher levels of cell reproduction.
This invention also comprises a culture of cells which has been treated by this method, and cells descended from cells which have been treated according to this method.
REFERENCES:
patent: 4376110 (1983-03-01), David et al.
patent: 4535058 (1985-08-01), Weinberg et al.
Belyagva et al., Mikrobiological 46(2): 300-303 (1977).
Bold et al. The Plant Kingdom, Prentice-Hall, Englewood Cliffs, NJ. 1987. p. 5.
Brock et al. Basic Microbiology with Applications, Prentice-Hall, Englewood Cliffs, NJ, 1986. pp. 154-155.
Stanier et al. The Microbial World, Prentice-Hall, Englewood Cliffs, NJ. 1986. pp. 249, 254, 525.
White et al, Construction of linkage maps with DNA markers for human chromosomes, Nature, Jan. 10, 1985, at 101.
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