Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2004-01-26
2009-11-10
Bunner, Bridget E (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C536S023400, C435S007100
Reexamination Certificate
active
07615610
ABSTRACT:
The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.
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Lefkowitz Robert J.
Shenoy Sudha
Brezner David J.
Bunner Bridget E
Duke University
Howard Zachary C
Morgan & Lewis & Bockius, LLP
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