Modified thermostable DNA polymerase derived from pyrococcus sp.

Details Modified thermostable DNA polymerase derived from pyrococcus sp. Modified thermostable DNA polymerase derived from pyrococcus sp.

1997-07-29

1999-12-28

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435194, C12P 1934, C12N 912

Patent

active

060080256

ABSTRACT:
A modified thermostable DNA polymerase having 5% or less of the 3'-5' exonuclease activity of the enzyme before modification and a DNA polymerase composition for amplifying nucleic acid, which comprises the modified thermostable DNA polymerase having 0 to 5% of the 3'-5' exonuclease activity of the enzyme before modification and an unmodified thermostable DNA polymerase having 3'-5' exonuclease activity or a modified thermostable DNA polymerase having 100 to 6% of the 3'-5' exonuclease activity of a thermostable DNA polymerase before modification; a method for amplifying nucleic acid by use of said modified thermostable polymerase or said DNA polymerase composition; and a reagent therefor.

REFERENCES:
patent: 5489523 (1996-02-01), Mathur
patent: 5512462 (1996-04-01), Cheng
patent: 5545552 (1996-08-01), Mathur
patent: 5556772 (1996-09-01), Sorge et al.
patent: 5602011 (1997-02-01), Luhm et al.
Southworth et al., Proc. Natl. Acad. Sci. USA 93, 5281-5285, 1996.
Kitabayashi et al., FASEB J. 10(6), A1245 (Abstract), 1996.
Takagi et al., App. Environ. Microbiol. 63(11), 4504-4510 1997.

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